B-type natriuretic peptide and heart failure in patients with ventricular septal defect: A pilot study

Michael A. Paul*, Carl L Backer, Helen Binns, Constantine Mavroudis, Catherine L. Webb, Ram Yogev, Wayne H. Franklin

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In adults without congenital heart disease, B-type natriuretic peptide (BNP) has been shown to be a very sensitive and specific marker of heart failure. The utility of BNP as a marker of clinical heart failure in children with a ventricular septal defect (VSD) has yet to be determined. A prospective, observational study evaluated BNP levels and other measures of heart failure. Eligible patients were <2 years old, scheduled to undergo surgical repair of a VSD, and without other significant structural heart disease. Data collected before and after surgical repair included echocardiographic measurements, electrocardiographic (ECG) findings, Ross score, BNP measurements, and weight gain. A total of 21 patients were enrolled and 14 patients had complete postoperative follow-up data. For patients with complete data, mean BNP decreased by 94 pg/ml (118 pre vs. 24 post; paired t -test, p = 0.041), mean left ventricular end-diastolic dimension z-score decreased by 1.75 (+0.86 vs. -0.89; paired t -test, p = 0.013), mean weight z-score change per month increased by 0.35 (-0.25 vs. +0.10; Wilcoxon test, p = 0.013), and the incidence of biventricular hypertrophy on ECG decreased (46% vs. 0%; McNemar test, p = 0.031). The change in BNP showed a trend toward a negative correlation with weight z-score change per month ( r = -0.531, p = 0.075). In conclusion, BNP, along with other measures of heart failure, decreased following VSD repair, and the change in BNP was most closely correlated with improved weight gain.

Original languageEnglish (US)
Pages (from-to)1094-1097
Number of pages4
JournalPediatric Cardiology
Volume30
Issue number8
DOIs
StatePublished - Jan 1 2009

Fingerprint

Brain Natriuretic Peptide
Ventricular Heart Septal Defects
Heart Failure
Weight Gain
Heart Diseases
Weights and Measures
Hypertrophy
Observational Studies
Biomarkers
Prospective Studies
Incidence

Keywords

  • B-type natriuretic peptide
  • Congenital heart disease
  • Ventricular septal defect

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

Cite this

Paul, Michael A. ; Backer, Carl L ; Binns, Helen ; Mavroudis, Constantine ; Webb, Catherine L. ; Yogev, Ram ; Franklin, Wayne H. / B-type natriuretic peptide and heart failure in patients with ventricular septal defect : A pilot study. In: Pediatric Cardiology. 2009 ; Vol. 30, No. 8. pp. 1094-1097.
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B-type natriuretic peptide and heart failure in patients with ventricular septal defect : A pilot study. / Paul, Michael A.; Backer, Carl L; Binns, Helen; Mavroudis, Constantine; Webb, Catherine L.; Yogev, Ram; Franklin, Wayne H.

In: Pediatric Cardiology, Vol. 30, No. 8, 01.01.2009, p. 1094-1097.

Research output: Contribution to journalArticle

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T1 - B-type natriuretic peptide and heart failure in patients with ventricular septal defect

T2 - A pilot study

AU - Paul, Michael A.

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AU - Binns, Helen

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AU - Webb, Catherine L.

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AU - Franklin, Wayne H.

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