TY - JOUR
T1 - Baby budgeting
T2 - Oocyte cryopreservation in women delaying reproduction can reduce cost per live birth
AU - Devine, Kate
AU - Mumford, Sunni L.
AU - Goldman, Kara Nicole
AU - Hodes-Wertz, Brooke
AU - Druckenmiller, Sarah
AU - Propst, Anthony M.
AU - Noyes, Nicole
N1 - Funding Information:
Supported by the Program in Reproductive and Adult Endocrinology and the Intramural Research Program, National Institute of Child Health and Human Development, National Institutes of Health , Bethesda, Maryland.
Publisher Copyright:
© 2015 by American Society for Reproductive Medicine.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Objective To determine whether oocyte cryopreservation for deferred reproduction is cost effective per live birth using a model constructed from observed clinical practice. Design Decision-tree mathematical model with sensitivity analyses. Setting Not applicable. Patient(s) A simulated cohort of women wishing to delay childbearing until age 40 years. Intervention(s) Not applicable. Main Outcome Measure(s) Cost per live birth. Result(s) Our primary model predicted that oocyte cryopreservation at age 35 years by women planning to defer pregnancy attempts until age 40 years would decrease cost per live birth from $55,060 to $39,946 (and increase the odds of live birth from 42% to 62% by the end of the model), indicating that oocyte cryopreservation is a cost-effective strategy relative to forgoing it. If fresh autologous assisted reproductive technology (ART) was added at age 40 years, before thawing oocytes, 74% obtained a live birth, and cost per live birth increased to $61,887. Separate sensitivity analyses demonstrated that oocyte cryopreservation remained cost effective as long as performed before age 38 years, and more than 49% of those women not obtaining a spontaneously conceived live birth returned to thaw oocytes. Conclusion(s) In women who plan to delay childbearing until age 40 years, oocyte cryopreservation before 38 years of age reduces the cost to obtain a live birth.
AB - Objective To determine whether oocyte cryopreservation for deferred reproduction is cost effective per live birth using a model constructed from observed clinical practice. Design Decision-tree mathematical model with sensitivity analyses. Setting Not applicable. Patient(s) A simulated cohort of women wishing to delay childbearing until age 40 years. Intervention(s) Not applicable. Main Outcome Measure(s) Cost per live birth. Result(s) Our primary model predicted that oocyte cryopreservation at age 35 years by women planning to defer pregnancy attempts until age 40 years would decrease cost per live birth from $55,060 to $39,946 (and increase the odds of live birth from 42% to 62% by the end of the model), indicating that oocyte cryopreservation is a cost-effective strategy relative to forgoing it. If fresh autologous assisted reproductive technology (ART) was added at age 40 years, before thawing oocytes, 74% obtained a live birth, and cost per live birth increased to $61,887. Separate sensitivity analyses demonstrated that oocyte cryopreservation remained cost effective as long as performed before age 38 years, and more than 49% of those women not obtaining a spontaneously conceived live birth returned to thaw oocytes. Conclusion(s) In women who plan to delay childbearing until age 40 years, oocyte cryopreservation before 38 years of age reduces the cost to obtain a live birth.
KW - ART
KW - Oocyte cryopreservation
KW - cost analysis
KW - fertility preservation
KW - vitrification
UR - http://www.scopus.com/inward/record.url?scp=84930930393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930930393&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2015.02.029
DO - 10.1016/j.fertnstert.2015.02.029
M3 - Article
C2 - 25813281
AN - SCOPUS:84930930393
SN - 0015-0282
VL - 103
SP - 1446-1453.e2
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 6
ER -