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BACE1 structure and function in health and Alzheimer's disease
Sarah L. Cole,
Roger Vassar
*
*
Corresponding author for this work
Neurology
Research output
:
Contribution to journal
›
Review article
›
peer-review
90
Scopus citations
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Keyphrases
Alzheimer's Disease
100%
Health Diseases
100%
β-site APP-cleaving Enzyme 1 (BACE1)
100%
Secretase
27%
Amyloid Precursor Protein
27%
Knock-in Mouse Model
18%
Alzheimer's Disease Treatment
18%
BACE1 Substrates
18%
Pathophysiology
9%
Neurodegenerative Diseases
9%
In Vivo Data
9%
Dysregulated
9%
Therapeutic Target
9%
Strong Correlation
9%
Pathological Lesions
9%
Disease States
9%
Therapeutic Strategies
9%
Protease
9%
Basic Biology
9%
Physiological Changes
9%
Rate-limiting Enzyme
9%
Key Risk Factors
9%
Amyloid Plaques
9%
Alzheimer's Disease Brain
9%
Behavior Modification
9%
Putative Functions
9%
Amyloid-β Peptide
9%
Aspartic Protease
9%
Biochemistry, Genetics and Molecular Biology
Secretase
100%
Enzyme
100%
Amyloid Precursor Protein
100%
Knockout Mouse
66%
Amyloid Protein
66%
Protease
66%
Beta-Secretase 1
33%
Pharmacology, Toxicology and Pharmaceutical Science
Alzheimer's Disease
100%
Secretase
37%
Amyloid Precursor Protein
37%
Knockout Mouse
25%
Proteinase
12%
Amyloid Protein
12%
Amyloid Plaque
12%
Beta Secretase 1
12%
Disease
12%
Combination Therapy
12%
Pathophysiology
12%
Aspartic Proteinase
12%
Neuroscience
Alzheimer's Disease
100%
Secretase
37%
Amyloid Precursor Protein
37%
Amyloid Protein
25%
In Vivo
12%
Neurodegenerative Disorder
12%
Proteinase
12%
Beta Secretase 1
12%
Aspartic Proteinase
12%