Baclofen for Intractable Hiccups

Allan M. Burke, Alexander B. White, Norman Brill

Research output: Contribution to journalLetterpeer-review

52 Scopus citations


To the Editor: The treatment of intractable hiccups is, by definition, difficult whether the cause is known or not. We describe two patients with lengthy histories of hiccups who had dramatic, sustained responses to moderate doses of baclofen. A 61-year-old man had renal failure secondary to membranous glomerulonephritis and had intractable hiccups for three years after the subclavian insertion of a Gore-Tex graft for hemodialysis. Antacids (cimetidine and ranitidine), chlorpromazine (up to 400 mg per day), carbamazepine, nifedipine (up to 60 mg per day, causing hypotension), lorazepam, clonazepam, diazepam, and amitriptyline were ineffective. The patient was given 5 mg of.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number20
StatePublished - Nov 17 1988

ASJC Scopus subject areas

  • Medicine(all)


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