Bacoside A downregulates matrix metalloproteinases 2 and 9 in DEN-induced hepatocellular carcinoma

Panneerselvam Janani, Kanakarajan Sivakumari*, Arumugam Geetha, Yuvaraj Sambandam, Chandrakesan Parthasarathy

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Cancer metastasis is a complex multi-step process, responsible for a majority of cancer-related deaths by affecting the critical organs and causing complications in therapies. Hepatocellular carcinoma is a multi-factorial disease and is the third most common cause of cancer related mortality worldwide. Clinical and experimental studies have shown that MMP-2 and MMP-9 are involved in tumor invasion and metastases and their elevated expression has been associated with poor prognosis. Our recent studies showed a strong anti-oxidant and hepatoprotective effects of bacoside A (BA) against carcinogen. Nevertheless the effect of BA on the activities and expression of MMP-2 and MMP-9 during hepatocellular carcinoma is not yet recognized. Therefore, the present study was designed to assess the same. Results of gelatin zymography study showed that BA co-treatment significantly decreased the activities of MMP-2 and MMP-9, which is increased during hepatocellular carcinoma. Further immunoblot analysis showed decreased expression of MMP-2 and MMP-9 in rats co-treated with BA compared to DEN-induced hepatocellular carcinoma. Our results reveal that BA exerts its anti-metastatic effect against DEN-induced hepatocellular carcinoma by inhibiting the activities and expressions of MMP-2 and MMP-9.

Original languageEnglish (US)
Pages (from-to)164-169
Number of pages6
JournalCell Biochemistry and Function
Volume28
Issue number2
DOIs
StatePublished - Mar 1 2010

Keywords

  • Bacoside A
  • Hepatocelluar carcinoma
  • MMP-2
  • MMP-9
  • N-nitroso diethylamine

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology

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