Abstract
Calmodulin-activated, adenylate cyclase toxin, a virulence factor produced by the human respiratory pathogen Bordetella pertussis, elicits marked accumulation of cyclic AMP in cell lines from rat pituitary tumors. This effect is associated with and apparently responsible for an enhanced release of prolactin and/or growth hormone from GH3, GH4C1 and 235-1 cells. The utility of this novel toxin in probing cyclic AMP-mediated responses is supported by these observations and studies with pertussis and cholera toxins.
Original language | English (US) |
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Pages (from-to) | 463-469 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 136 |
Issue number | 2 |
DOIs | |
State | Published - Apr 29 1986 |
Funding
Supported by RCDA lK04NS00601, NS18409, A118000, AM22125, AM32632, the Rockefeller and Pratt Foundations. We thank Dr. A. Rogol for the use of his RIA equipment and Dr. A. Weiss for her professional interest in these studies. The technical performance of Gwendolyn Myers, Gwen Baber, Robert Malcolm and Dr. George Vandenhof was superb as usual.
ASJC Scopus subject areas
- Molecular Biology
- Biophysics
- Biochemistry
- Cell Biology