Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells

J. Weiss; E. L. Hewlett; M. J. Cronin

doi:10.1016/0006-291X(86)90463-8

Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells

J. Weiss^*, E. L. Hewlett, M. J. Cronin

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Calmodulin-activated, adenylate cyclase toxin, a virulence factor produced by the human respiratory pathogen Bordetella pertussis, elicits marked accumulation of cyclic AMP in cell lines from rat pituitary tumors. This effect is associated with and apparently responsible for an enhanced release of prolactin and/or growth hormone from GH₃, GH₄C₁ and 235-1 cells. The utility of this novel toxin in probing cyclic AMP-mediated responses is supported by these observations and studies with pertussis and cholera toxins.

Original language	English (US)
Pages (from-to)	463-469
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	136
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(86)90463-8
State	Published - Apr 29 1986

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(86)90463-8

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title = "Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells",

abstract = "Calmodulin-activated, adenylate cyclase toxin, a virulence factor produced by the human respiratory pathogen Bordetella pertussis, elicits marked accumulation of cyclic AMP in cell lines from rat pituitary tumors. This effect is associated with and apparently responsible for an enhanced release of prolactin and/or growth hormone from GH3, GH4C1 and 235-1 cells. The utility of this novel toxin in probing cyclic AMP-mediated responses is supported by these observations and studies with pertussis and cholera toxins.",

author = "J. Weiss and Hewlett, {E. L.} and Cronin, {M. J.}",

note = "Funding Information: Supported by RCDA lK04NS00601, NS18409, A118000, AM22125, AM32632, the Rockefeller and Pratt Foundations. We thank Dr. A. Rogol for the use of his RIA equipment and Dr. A. Weiss for her professional interest in these studies. The technical performance of Gwendolyn Myers, Gwen Baber, Robert Malcolm and Dr. George Vandenhof was superb as usual.",

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T1 - Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells

AU - Weiss, J.

AU - Hewlett, E. L.

AU - Cronin, M. J.

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PY - 1986/4/29

Y1 - 1986/4/29

N2 - Calmodulin-activated, adenylate cyclase toxin, a virulence factor produced by the human respiratory pathogen Bordetella pertussis, elicits marked accumulation of cyclic AMP in cell lines from rat pituitary tumors. This effect is associated with and apparently responsible for an enhanced release of prolactin and/or growth hormone from GH3, GH4C1 and 235-1 cells. The utility of this novel toxin in probing cyclic AMP-mediated responses is supported by these observations and studies with pertussis and cholera toxins.

AB - Calmodulin-activated, adenylate cyclase toxin, a virulence factor produced by the human respiratory pathogen Bordetella pertussis, elicits marked accumulation of cyclic AMP in cell lines from rat pituitary tumors. This effect is associated with and apparently responsible for an enhanced release of prolactin and/or growth hormone from GH3, GH4C1 and 235-1 cells. The utility of this novel toxin in probing cyclic AMP-mediated responses is supported by these observations and studies with pertussis and cholera toxins.

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Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells

Abstract

ASJC Scopus subject areas

UN SDGs

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