Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells

J. Weiss*, E. L. Hewlett, M. J. Cronin

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Calmodulin-activated, adenylate cyclase toxin, a virulence factor produced by the human respiratory pathogen Bordetella pertussis, elicits marked accumulation of cyclic AMP in cell lines from rat pituitary tumors. This effect is associated with and apparently responsible for an enhanced release of prolactin and/or growth hormone from GH3, GH4C1 and 235-1 cells. The utility of this novel toxin in probing cyclic AMP-mediated responses is supported by these observations and studies with pertussis and cholera toxins.

Original languageEnglish (US)
Pages (from-to)463-469
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume136
Issue number2
DOIs
StatePublished - Apr 29 1986

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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