Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells

J. Weiss; E. L. Hewlett; M. J. Cronin

doi:10.1016/0006-291X(86)90463-8

Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells

J. Weiss^*, E. L. Hewlett, M. J. Cronin

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

Calmodulin-activated, adenylate cyclase toxin, a virulence factor produced by the human respiratory pathogen Bordetella pertussis, elicits marked accumulation of cyclic AMP in cell lines from rat pituitary tumors. This effect is associated with and apparently responsible for an enhanced release of prolactin and/or growth hormone from GH₃, GH₄C₁ and 235-1 cells. The utility of this novel toxin in probing cyclic AMP-mediated responses is supported by these observations and studies with pertussis and cholera toxins.

Original language	English (US)
Pages (from-to)	463-469
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	136
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(86)90463-8
State	Published - Apr 29 1986

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Weiss, J., Hewlett, E. L., & Cronin, M. J. (1986). Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells. Biochemical and Biophysical Research Communications, 136(2), 463-469. https://doi.org/10.1016/0006-291X(86)90463-8

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