Bactericidal activity of the fluoroquinolone WIN 57273 against high-level gentamicin-resistant Enterococcus faecalis

G. A. Noskin*, P. Mehl, J. R. Warren

*Corresponding author for this work

Research output: Contribution to journalComment/debate

4 Scopus citations


The fluoroquinolone WIN 57273 showed identical bactericidal activities (MBC for 90% of the strains = 0.25 μg/ml) for bacteremic strains of Enterococcus faecalis with and without high-level gentamicin resistance. WIN 57273 was bactericidal in time-kill measurements with highly gentamicin- resistant, ciprofloxacin-susceptible strains of E. faecalis. However, WIN 57273 was indifferent with penicillin for gentamicin-resistant E. faecalis and was not bactericidal for ciprofloxacin-resistant E. faecalis.

Original languageEnglish (US)
Pages (from-to)2470-2473
Number of pages4
JournalAntimicrobial agents and chemotherapy
Issue number11
StatePublished - Jan 1 1993


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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