Bactericidal activity of the fluoroquinolone WIN 57273 against high-level gentamicin-resistant Enterococcus faecalis

Gary A Noskin*, P. Mehl, J. R. Warren

*Corresponding author for this work

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Abstract

The fluoroquinolone WIN 57273 showed identical bactericidal activities (MBC for 90% of the strains = 0.25 μg/ml) for bacteremic strains of Enterococcus faecalis with and without high-level gentamicin resistance. WIN 57273 was bactericidal in time-kill measurements with highly gentamicin- resistant, ciprofloxacin-susceptible strains of E. faecalis. However, WIN 57273 was indifferent with penicillin for gentamicin-resistant E. faecalis and was not bactericidal for ciprofloxacin-resistant E. faecalis.

Original languageEnglish (US)
Pages (from-to)2470-2473
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume37
Issue number11
DOIs
StatePublished - Jan 1 1993

Fingerprint

Enterococcus faecalis
Fluoroquinolones
Gentamicins
Ciprofloxacin
Penicillins

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

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title = "Bactericidal activity of the fluoroquinolone WIN 57273 against high-level gentamicin-resistant Enterococcus faecalis",
abstract = "The fluoroquinolone WIN 57273 showed identical bactericidal activities (MBC for 90{\%} of the strains = 0.25 μg/ml) for bacteremic strains of Enterococcus faecalis with and without high-level gentamicin resistance. WIN 57273 was bactericidal in time-kill measurements with highly gentamicin- resistant, ciprofloxacin-susceptible strains of E. faecalis. However, WIN 57273 was indifferent with penicillin for gentamicin-resistant E. faecalis and was not bactericidal for ciprofloxacin-resistant E. faecalis.",
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Bactericidal activity of the fluoroquinolone WIN 57273 against high-level gentamicin-resistant Enterococcus faecalis. / Noskin, Gary A; Mehl, P.; Warren, J. R.

In: Antimicrobial Agents and Chemotherapy, Vol. 37, No. 11, 01.01.1993, p. 2470-2473.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Bactericidal activity of the fluoroquinolone WIN 57273 against high-level gentamicin-resistant Enterococcus faecalis

AU - Noskin, Gary A

AU - Mehl, P.

AU - Warren, J. R.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The fluoroquinolone WIN 57273 showed identical bactericidal activities (MBC for 90% of the strains = 0.25 μg/ml) for bacteremic strains of Enterococcus faecalis with and without high-level gentamicin resistance. WIN 57273 was bactericidal in time-kill measurements with highly gentamicin- resistant, ciprofloxacin-susceptible strains of E. faecalis. However, WIN 57273 was indifferent with penicillin for gentamicin-resistant E. faecalis and was not bactericidal for ciprofloxacin-resistant E. faecalis.

AB - The fluoroquinolone WIN 57273 showed identical bactericidal activities (MBC for 90% of the strains = 0.25 μg/ml) for bacteremic strains of Enterococcus faecalis with and without high-level gentamicin resistance. WIN 57273 was bactericidal in time-kill measurements with highly gentamicin- resistant, ciprofloxacin-susceptible strains of E. faecalis. However, WIN 57273 was indifferent with penicillin for gentamicin-resistant E. faecalis and was not bactericidal for ciprofloxacin-resistant E. faecalis.

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JO - Antimicrobial Agents and Chemotherapy

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