TY - JOUR
T1 - Balancing the risks and benefits of oxygen therapy in critically ill adults
AU - Budinger, G. R.Scott
AU - Mutlu, Gökhan M.
N1 - Funding Information:
Funding/Support: This study was funded by the National Institutes of Health [Grants ES015024, ES013995, HL071643, and HL092963] ; The Northwestern Memorial Foundation Dixon Awards; and The Veterans Administration.
PY - 2013/4
Y1 - 2013/4
N2 - Oxygen therapy is an integral part of the treatment of critically ill patients. Maintenance of adequate oxygen delivery to vital organs often requires the administration of supplemental oxygen, sometimes at high concentrations. Although oxygen therapy is lifesaving, it may be associated with deleterious effects when administered for prolonged periods at high concentrations. Here, we review the recent advances in our understanding of the molecular responses to hypoxia and high levels of oxygen and review the current guidelines for oxygen therapy in critically ill patients.
AB - Oxygen therapy is an integral part of the treatment of critically ill patients. Maintenance of adequate oxygen delivery to vital organs often requires the administration of supplemental oxygen, sometimes at high concentrations. Although oxygen therapy is lifesaving, it may be associated with deleterious effects when administered for prolonged periods at high concentrations. Here, we review the recent advances in our understanding of the molecular responses to hypoxia and high levels of oxygen and review the current guidelines for oxygen therapy in critically ill patients.
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U2 - 10.1378/chest.12-1215
DO - 10.1378/chest.12-1215
M3 - Article
C2 - 23546490
AN - SCOPUS:84875977782
SN - 0012-3692
VL - 143
SP - 1151
EP - 1162
JO - Diseases of the chest
JF - Diseases of the chest
IS - 4
ER -