Balancing the risks and benefits of oxygen therapy in critically ill adults

G. R.Scott Budinger*, Gökhan M. Mutlu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Oxygen therapy is an integral part of the treatment of critically ill patients. Maintenance of adequate oxygen delivery to vital organs often requires the administration of supplemental oxygen, sometimes at high concentrations. Although oxygen therapy is lifesaving, it may be associated with deleterious effects when administered for prolonged periods at high concentrations. Here, we review the recent advances in our understanding of the molecular responses to hypoxia and high levels of oxygen and review the current guidelines for oxygen therapy in critically ill patients.

Original languageEnglish (US)
Pages (from-to)1151-1162
Number of pages12
Issue number4
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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