BALB/c substrain differences in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease

Simone M. Nicholson, Jeffrey D. Peterson, Stephen D. Miller, Kegiang Wang, Mauro C. Dal Canto, Roger W. Melvold*

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

We report differences among BALB/c substrains in susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease, an immune-mediated inflammatory demyelinating disease and experimental model for human multiple sclerosis. BALB/cJ and BALB/cAnNCr mice are susceptible, while BALB/cByJ and BALB/cCum are resistant. Hybrids between BALB/cBy and BALB/cAnNCr were intermediate, although closer to the resistant parent. Backcrosses gave results compatible with differential susceptibility being related to a single segregating locus. Exposure of resistant BALB/cByJ mice to low dose irradiation, 2 days prior to infection, rendered them susceptible to TMEV-induced demyelination. The susceptibility pattern of TMEV-induced demyelinating disease among BALB/c substrains is distinct from those of several autoimmune disorders.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalJournal of Neuroimmunology
Volume52
Issue number1
DOIs
StatePublished - Jun 1994

Keywords

  • Autoimmunity
  • BALB/c
  • Demyelinating disease
  • Multiple sclerosis
  • Theiler's murine encephalomyelitis virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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