Barriers to translating emerging genetic research on smoking into clinical practice: Perspectives of primary care physicians

Alexandra E. Shields*, David Blumenthal, Kevin B. Weiss, Catherine B. Comstock, Douglas Currivan, Caryn Lerman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


OBJECTIVE: Smoking remains the leading cause of preventable death nationally. Emerging research may lead to improved smoking cessation treatment options, including tailoring treatment by genotype. Our objective was to assess primary care physicians' attitudes toward new genetic-based approaches to smoking treatment. DESIGN AND SETTING: A 2002 national survey of primary care physicians. Respondents were randomly assigned a survey including 1 of 2 scenarios: a scenario in which a new test to tailor smoking treatment was described as a "genetic" test or one in which the new test was described as a "serum protein" test. PARTICIPANTS: The study sample was randomly drawn from all U.S. primary care physicians in the American Medical Association Masterfile (e.g., those with a primary specialty of internal medicine, family practice, or general practice). Of 2,000 sampled physicians, 1.120 responded, yielding a response rate of 62.3%. MEASUREMENTS AND MAIN RESULTS: Controlling for physician and practice characteristics, describing a new test as "genetic" resulted in a regression-adjusted mean adoption score of 73.5, compared to a score of 82.5 for a nongenetic test, reflecting an 11% reduction in physicians' likelihood of offering such a test to their patients. CONCLUSIONS: Merely describing a new test to tailor smoking treatment as "genetic" poses a significant barrier to physician adoption. Considering national estimates of those who smoke on a daily basis, this 11% reduction in adoption scores would translate into 3.9 million smokers who would not be offered a new genetic-based treatment for smoking. While emerging genetic research may lead to improved smoking treatment, the potential of novel interventions will likely go unrealized unless barriers to clinical integration are addressed.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalJournal of general internal medicine
Issue number2
StatePublished - Feb 2005


  • Attitude of health personnel
  • Genetic screening
  • Physicians
  • Smoking cessation

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Barriers to translating emerging genetic research on smoking into clinical practice: Perspectives of primary care physicians'. Together they form a unique fingerprint.

Cite this