Basal bodies in Xenopus

Siwei Zhang; Brian J. Mitchell

doi:10.1186/s13630-016-0024-6

Basal bodies in Xenopus

Siwei Zhang, Brian J. Mitchell^*

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Xenopus has been one of the earliest and most important vertebrate model organisms for investigating the role and structure of basal bodies. Early transmission electron microscopy studies in Xenopus revealed the fine structures of Xenopus basal bodies and their accessory structures. Subsequent investigations using multiciliated cells in the Xenopus epidermis have further revealed many important features regarding the transcriptional regulation of basal body amplification as well as the regulation of basal body/cilia polarity. Future basal body research using Xenopus is expected to focus on the application of modern genome editing techniques (CRISPR/TALEN) to characterize the components of basal body proteins and their molecular functions.

Original language	English (US)
Article number	2
Journal	Cilia
Volume	5
Issue number	1
DOIs	https://doi.org/10.1186/s13630-016-0024-6
State	Published - Feb 3 2016

Keywords

Basal body
Centriole
Cilia
Ciliogenesis
Deuterosome
Multiciliated cells
Xenopus

ASJC Scopus subject areas

Cell Biology

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10.1186/s13630-016-0024-6

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title = "Basal bodies in Xenopus",

abstract = "Xenopus has been one of the earliest and most important vertebrate model organisms for investigating the role and structure of basal bodies. Early transmission electron microscopy studies in Xenopus revealed the fine structures of Xenopus basal bodies and their accessory structures. Subsequent investigations using multiciliated cells in the Xenopus epidermis have further revealed many important features regarding the transcriptional regulation of basal body amplification as well as the regulation of basal body/cilia polarity. Future basal body research using Xenopus is expected to focus on the application of modern genome editing techniques (CRISPR/TALEN) to characterize the components of basal body proteins and their molecular functions.",

keywords = "Basal body, Centriole, Cilia, Ciliogenesis, Deuterosome, Multiciliated cells, Xenopus",

author = "Siwei Zhang and Mitchell, {Brian J.}",

note = "Funding Information: We would like to thank Sun Kim and Jennifer Mitchell for helpful comments on the manuscript. BJM was supported by NIH‑NIMGS 2R01GM089970. Publisher Copyright: {\textcopyright} 2016 Zhang and Mitchell.",

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AU - Zhang, Siwei

AU - Mitchell, Brian J.

N1 - Funding Information: We would like to thank Sun Kim and Jennifer Mitchell for helpful comments on the manuscript. BJM was supported by NIH‑NIMGS 2R01GM089970. Publisher Copyright: © 2016 Zhang and Mitchell.

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N2 - Xenopus has been one of the earliest and most important vertebrate model organisms for investigating the role and structure of basal bodies. Early transmission electron microscopy studies in Xenopus revealed the fine structures of Xenopus basal bodies and their accessory structures. Subsequent investigations using multiciliated cells in the Xenopus epidermis have further revealed many important features regarding the transcriptional regulation of basal body amplification as well as the regulation of basal body/cilia polarity. Future basal body research using Xenopus is expected to focus on the application of modern genome editing techniques (CRISPR/TALEN) to characterize the components of basal body proteins and their molecular functions.

AB - Xenopus has been one of the earliest and most important vertebrate model organisms for investigating the role and structure of basal bodies. Early transmission electron microscopy studies in Xenopus revealed the fine structures of Xenopus basal bodies and their accessory structures. Subsequent investigations using multiciliated cells in the Xenopus epidermis have further revealed many important features regarding the transcriptional regulation of basal body amplification as well as the regulation of basal body/cilia polarity. Future basal body research using Xenopus is expected to focus on the application of modern genome editing techniques (CRISPR/TALEN) to characterize the components of basal body proteins and their molecular functions.

KW - Basal body

KW - Centriole

KW - Cilia

KW - Ciliogenesis

KW - Deuterosome

KW - Multiciliated cells

KW - Xenopus

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DO - 10.1186/s13630-016-0024-6

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Basal bodies in Xenopus

Abstract

Keywords

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