Basal cell carcinoma with pulmonary and lymph node metastasis causing death

June K. Robinson*, Madhu Dahiya

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Background: The incidence of metastatic basal cell carcinoma ranges from 0.003% to 0.55%. The 230 reported cases most often occurred in long-standing recurrent lesions and appeared in regional nodes or the lungs. Observations: The stromal dependence of the tumor provides an explanation for the nonmetastasizing nature of basal cell carcinoma. The dense fibrous stroma of the lymph node in the case of metastatic basal cell carcinoma reported in the present study is similar to other reported cases with metastases to lymph nodes, bone, bone marrow, glands, and subcutaneous tissue. Conclusions: This metastatic basal cell carcinoma demonstrated lymphatic and hematogenous dissemination to the lungs and lymph nodes. A dense accumulation of microvessels was present at the boundary of the tumor nests and dermal stroma and in the stroma surrounding the tumor in the lymph node.

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
JournalArchives of dermatology
Volume139
Issue number5
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Dermatology

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