Basal Plate Myometrial Fibers and Hypertensive Disorders of Pregnancy: A Case–Control Study

Ann A. Wang*, Linda M Ernst, Emily S. Miller

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Introduction: Basal plate myometrium (BPMYO), the pathological presence of myometrial fibers in the basal plate, is a common finding on pathological examination of the placenta, yet its clinical correlates are not well studied. As myometrial fibers are frequently located in proximity to poorly converted maternal spiral arteries, our objective was to determine whether BPMYO is associated with hypertensive disorders of pregnancy (HDP), a well-known clinical sequela of abnormal maternal artery remodeling. Methods: This case–control study included women who delivered a live-born singleton gestation whose placentas were sent for pathological examination. Cases were women with HDP (gestational hypertension, preeclampsia, or HELLP syndrome) as defined by American College of Obstetricians and Gynecologists. Controls were women without HDP. Women with chronic hypertension were excluded. The primary outcome was the presence of BPMYO. Secondary outcomes included the pathologic stage of BPMYO and the incidence of pathologically defined accreta. Each outcome was compared between cases and controls in bivariable and multivariable analyses. Results: Of the 306 women who met inclusion criteria, 230 (75%) had HDP. BPMYO was present in 99 (32%) of placentas. Compared to controls, cases were younger, had higher body mass index, and were more likely to have diabetes, be nulliparous, deliver preterm, and have had a prior cesarean. There were no differences in the incidence of BPMYO, stage of BPMYO, or incidence of pathologically defined accreta between cases and controls. These findings persisted after controlling for potential confounders. Conclusions: Although BPMYO may be more common in the setting of abnormal placental vasculature, there is no significant association between BPMYO and HDP.

Original languageEnglish (US)
Pages (from-to)296-299
Number of pages4
JournalPediatric and Developmental Pathology
Volume21
Issue number3
DOIs
StatePublished - May 1 2018

Keywords

  • basal plate myometrial fibers
  • fetal
  • hypertension
  • pathology
  • placenta
  • preeclampsia
  • pregnancy
  • spiral arteries
  • vascular

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Basal Plate Myometrial Fibers and Hypertensive Disorders of Pregnancy: A Case–Control Study'. Together they form a unique fingerprint.

  • Cite this