TY - JOUR
T1 - Baseline Quality-of-Life of Caregivers of Patients With Heart Failure Prior to Advanced Therapies
T2 - Findings From the Sustaining Quality of Life of the Aged: Transplant or Mechanical Support (SUSTAIN-IT) Study
AU - PETTY, M. G.
AU - WU, T.
AU - ANDREI, A. C.
AU - BALDRIDGE, A.
AU - WARZECHA, A.
AU - KAO, A.
AU - SPERTUS, J.
AU - HSICH, E.
AU - DEW, M. A.
AU - PHAM, D.
AU - YANCY, C.
AU - HARTUPEE, J.
AU - COTTS, W.
AU - PAMBOUKIAN, S. V.
AU - PAGANI, F.
AU - LAMPERT, B.
AU - JOHNSON, M.
AU - MURRAY, M.
AU - TEKEDA, K.
AU - YUZEFPOLSKAYA, M.
AU - SILVESTRY, S.
AU - KIRKLIN, J. K.
AU - GRADY, K. L.
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/7
Y1 - 2022/7
N2 - Background: We compared health-related quality of life (HRQOL), depressive symptoms, anxiety, and burden in caregivers of older patients with heart failure based on the intended therapy goal of the patient: awaiting heart transplantation (HT) with or without mechanical circulatory support (MCS) or prior to long-term MCS; and we identified factors associated with HRQOL. Methods: Caregivers (n = 281) recruited from 13 HT and MCS programs in the United States completed measures of HRQOL (EQ-5D-3L), depressive symptoms (PHQ-8), anxiety (STAI-state), and burden (Oberst Caregiving Burden Scale). Analyses included ANOVA, Kruskal-Wallis tests, χ2 tests, and linear regression. Results: The majority of caregivers were female, white spouses with ≤ 2 comorbidities, median [Q1,Q3] age = 62 [57.8, 67.0] years. Caregivers (HT with MCS = 87, HT without MCS = 98, long-term MCS = 96) reported similarly high baseline HRQOL (EQ-5D-3L visual analog scale median score = 90; P = 0.67 for all groups) and low levels of depressive symptoms. STAI-state median scores were higher in the long-term MCS group vs the HT groups with and without MCS, (38 vs 32 vs 31; P < 0.001), respectively. Burden (task: time spent/difficulty) differed significantly among groups. Caregiver factors (number of comorbidities, diabetes and higher anxiety levels) were significantly associated with worse caregiver HRQOL, R2 = 26%. Conclusions: Recognizing caregiver-specific factors, including comorbidities and anxiety, associated with the HRQOL of caregivers of these older patients with advanced HF may guide support strategies.
AB - Background: We compared health-related quality of life (HRQOL), depressive symptoms, anxiety, and burden in caregivers of older patients with heart failure based on the intended therapy goal of the patient: awaiting heart transplantation (HT) with or without mechanical circulatory support (MCS) or prior to long-term MCS; and we identified factors associated with HRQOL. Methods: Caregivers (n = 281) recruited from 13 HT and MCS programs in the United States completed measures of HRQOL (EQ-5D-3L), depressive symptoms (PHQ-8), anxiety (STAI-state), and burden (Oberst Caregiving Burden Scale). Analyses included ANOVA, Kruskal-Wallis tests, χ2 tests, and linear regression. Results: The majority of caregivers were female, white spouses with ≤ 2 comorbidities, median [Q1,Q3] age = 62 [57.8, 67.0] years. Caregivers (HT with MCS = 87, HT without MCS = 98, long-term MCS = 96) reported similarly high baseline HRQOL (EQ-5D-3L visual analog scale median score = 90; P = 0.67 for all groups) and low levels of depressive symptoms. STAI-state median scores were higher in the long-term MCS group vs the HT groups with and without MCS, (38 vs 32 vs 31; P < 0.001), respectively. Burden (task: time spent/difficulty) differed significantly among groups. Caregiver factors (number of comorbidities, diabetes and higher anxiety levels) were significantly associated with worse caregiver HRQOL, R2 = 26%. Conclusions: Recognizing caregiver-specific factors, including comorbidities and anxiety, associated with the HRQOL of caregivers of these older patients with advanced HF may guide support strategies.
KW - Caregiver
KW - health-related quality of life (HRQOL)
KW - heart failure
KW - heart transplant
KW - mechanical circulatory support
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U2 - 10.1016/j.cardfail.2022.03.358
DO - 10.1016/j.cardfail.2022.03.358
M3 - Article
C2 - 35470057
AN - SCOPUS:85132446721
SN - 1071-9164
VL - 28
SP - 1137
EP - 1148
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 7
ER -