Basic and clinical immunology of Siglecs

Stephan Von Gunten, Bruce S. Bochner

Research output: Chapter in Book/Report/Conference proceedingChapter

109 Scopus citations

Abstract

Siglecs are cell-surface proteins found primarily on hematopoietic cells. By definition, they are members of the immunoglobulin gene super-family and bind sialic acid. Most contain cytoplasmic tyrosine motifs implicated in cell signaling. This review will first summarize characteristics common and unique to Siglecs, followed by a discussion of each human Siglec in numerical order, mentioning in turn its closest murine ortholog or paralog. Each section will describe its pattern of cellular expression, latest known immune functions, ligands, and signaling pathways, with the focus being predominantly on CD33-related Siglecs. Potential clinical and therapeutic implications of each Siglec will also be covered.

Original languageEnglish (US)
Title of host publicationThe Year in Immunology 2008
PublisherBlackwell Publishing Inc.
Pages61-82
Number of pages22
ISBN (Print)9781573317290
DOIs
StatePublished - Nov 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1143
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Human
  • ITAM
  • ITIM
  • Lectin
  • Leukocyte
  • Mouse
  • Sialic acid
  • Siglec

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Von Gunten, S., & Bochner, B. S. (2008). Basic and clinical immunology of Siglecs. In The Year in Immunology 2008 (pp. 61-82). (Annals of the New York Academy of Sciences; Vol. 1143). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1443.011