@article{f36cc919bf0c4ef58f7e46e202d5e3c2,
title = "Basic Mechanisms of Pain in Osteoarthritis: Experimental Observations and New Perspectives",
abstract = "The specific changes in the peripheral neuronal pathways underlying joint pain in osteoarthritis are the focus of this review. The plasticity of the nociceptive system in osteoarthritis and how this involves changes in the structural, physiologic, and genetic properties of neurons in pain pathways are discussed. The role of the neurotrophin, nerve growth factor, in these pathogenic processes is discussed. Finally, how neuronal pathways are modified by interaction with the degenerating joint tissues they innervate and with the innate immune system is considered. These extensive cellular interactions provide a substrate for identification of targets for osteoarthritis pain.",
keywords = "DRG neurons, Innate immunity, NGF, Osteoarthritis, Pain, Sensitization",
author = "Malfait, {Anne Marie} and Miller, {Rachel E.} and Miller, {Richard J.}",
note = "Funding Information: The authors thank the National Institutes of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), grant numbers R01AR060364 to A.-M. Malfait and R01AR064251 to A.-M. Malfait, and R.J. Miller, and K01AR070328 to R.E. Miller. A.-M. Malfait is supported by the George W. Stuppy, MD, Chair of Arthritis at Rush University. AM Malfait has received consulting fees from Eli Lilly/Pfizer, as well as from Ceva and from Vizuri. Funding Information: The authors thank the National Institutes of Health ( National Institute of Arthritis and Musculoskeletal and Skin Diseases ( NIAMS ), grant numbers R01AR060364 to A.-M. Malfait and R01AR064251 to A.-M. Malfait, and R.J. Miller, and K01AR070328 to R.E. Miller. A.-M. Malfait is supported by the George W. Stuppy, MD, Chair of Arthritis at Rush University. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = may,
doi = "10.1016/j.rdc.2020.12.002",
language = "English (US)",
volume = "47",
pages = "165--180",
journal = "Rheumatic Disease Clinics of North America",
issn = "0889-857X",
publisher = "W.B. Saunders Ltd",
number = "2",
}