Basic Mechanisms of Pain in Osteoarthritis: Experimental Observations and New Perspectives

Anne Marie Malfait; Rachel E. Miller; Richard J. Miller

doi:10.1016/j.rdc.2020.12.002

Basic Mechanisms of Pain in Osteoarthritis: Experimental Observations and New Perspectives

Anne Marie Malfait^*, Rachel E. Miller, Richard J. Miller

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

The specific changes in the peripheral neuronal pathways underlying joint pain in osteoarthritis are the focus of this review. The plasticity of the nociceptive system in osteoarthritis and how this involves changes in the structural, physiologic, and genetic properties of neurons in pain pathways are discussed. The role of the neurotrophin, nerve growth factor, in these pathogenic processes is discussed. Finally, how neuronal pathways are modified by interaction with the degenerating joint tissues they innervate and with the innate immune system is considered. These extensive cellular interactions provide a substrate for identification of targets for osteoarthritis pain.

Original language	English (US)
Pages (from-to)	165-180
Number of pages	16
Journal	Rheumatic Disease Clinics of North America
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/j.rdc.2020.12.002
State	Published - May 2021

Funding

The authors thank the National Institutes of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), grant numbers R01AR060364 to A.-M. Malfait and R01AR064251 to A.-M. Malfait, and R.J. Miller, and K01AR070328 to R.E. Miller. A.-M. Malfait is supported by the George W. Stuppy, MD, Chair of Arthritis at Rush University. AM Malfait has received consulting fees from Eli Lilly/Pfizer, as well as from Ceva and from Vizuri. The authors thank the National Institutes of Health ( National Institute of Arthritis and Musculoskeletal and Skin Diseases ( NIAMS ), grant numbers R01AR060364 to A.-M. Malfait and R01AR064251 to A.-M. Malfait, and R.J. Miller, and K01AR070328 to R.E. Miller. A.-M. Malfait is supported by the George W. Stuppy, MD, Chair of Arthritis at Rush University.

Keywords

DRG neurons
Innate immunity
NGF
Osteoarthritis
Pain
Sensitization

ASJC Scopus subject areas

Rheumatology

Access to Document

10.1016/j.rdc.2020.12.002

Cite this

@article{f36cc919bf0c4ef58f7e46e202d5e3c2,

title = "Basic Mechanisms of Pain in Osteoarthritis: Experimental Observations and New Perspectives",

abstract = "The specific changes in the peripheral neuronal pathways underlying joint pain in osteoarthritis are the focus of this review. The plasticity of the nociceptive system in osteoarthritis and how this involves changes in the structural, physiologic, and genetic properties of neurons in pain pathways are discussed. The role of the neurotrophin, nerve growth factor, in these pathogenic processes is discussed. Finally, how neuronal pathways are modified by interaction with the degenerating joint tissues they innervate and with the innate immune system is considered. These extensive cellular interactions provide a substrate for identification of targets for osteoarthritis pain.",

keywords = "DRG neurons, Innate immunity, NGF, Osteoarthritis, Pain, Sensitization",

author = "Malfait, {Anne Marie} and Miller, {Rachel E.} and Miller, {Richard J.}",

note = "Funding Information: The authors thank the National Institutes of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), grant numbers R01AR060364 to A.-M. Malfait and R01AR064251 to A.-M. Malfait, and R.J. Miller, and K01AR070328 to R.E. Miller. A.-M. Malfait is supported by the George W. Stuppy, MD, Chair of Arthritis at Rush University. AM Malfait has received consulting fees from Eli Lilly/Pfizer, as well as from Ceva and from Vizuri. Funding Information: The authors thank the National Institutes of Health ( National Institute of Arthritis and Musculoskeletal and Skin Diseases ( NIAMS ), grant numbers R01AR060364 to A.-M. Malfait and R01AR064251 to A.-M. Malfait, and R.J. Miller, and K01AR070328 to R.E. Miller. A.-M. Malfait is supported by the George W. Stuppy, MD, Chair of Arthritis at Rush University. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = may,

doi = "10.1016/j.rdc.2020.12.002",

language = "English (US)",

volume = "47",

pages = "165--180",

journal = "Rheumatic Disease Clinics of North America",

issn = "0889-857X",

publisher = "W.B. Saunders",

number = "2",

}

TY - JOUR

T1 - Basic Mechanisms of Pain in Osteoarthritis

T2 - Experimental Observations and New Perspectives

AU - Malfait, Anne Marie

AU - Miller, Rachel E.

AU - Miller, Richard J.

N1 - Funding Information: The authors thank the National Institutes of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), grant numbers R01AR060364 to A.-M. Malfait and R01AR064251 to A.-M. Malfait, and R.J. Miller, and K01AR070328 to R.E. Miller. A.-M. Malfait is supported by the George W. Stuppy, MD, Chair of Arthritis at Rush University. AM Malfait has received consulting fees from Eli Lilly/Pfizer, as well as from Ceva and from Vizuri. Funding Information: The authors thank the National Institutes of Health ( National Institute of Arthritis and Musculoskeletal and Skin Diseases ( NIAMS ), grant numbers R01AR060364 to A.-M. Malfait and R01AR064251 to A.-M. Malfait, and R.J. Miller, and K01AR070328 to R.E. Miller. A.-M. Malfait is supported by the George W. Stuppy, MD, Chair of Arthritis at Rush University. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2021/5

Y1 - 2021/5

N2 - The specific changes in the peripheral neuronal pathways underlying joint pain in osteoarthritis are the focus of this review. The plasticity of the nociceptive system in osteoarthritis and how this involves changes in the structural, physiologic, and genetic properties of neurons in pain pathways are discussed. The role of the neurotrophin, nerve growth factor, in these pathogenic processes is discussed. Finally, how neuronal pathways are modified by interaction with the degenerating joint tissues they innervate and with the innate immune system is considered. These extensive cellular interactions provide a substrate for identification of targets for osteoarthritis pain.

AB - The specific changes in the peripheral neuronal pathways underlying joint pain in osteoarthritis are the focus of this review. The plasticity of the nociceptive system in osteoarthritis and how this involves changes in the structural, physiologic, and genetic properties of neurons in pain pathways are discussed. The role of the neurotrophin, nerve growth factor, in these pathogenic processes is discussed. Finally, how neuronal pathways are modified by interaction with the degenerating joint tissues they innervate and with the innate immune system is considered. These extensive cellular interactions provide a substrate for identification of targets for osteoarthritis pain.

KW - DRG neurons

KW - Innate immunity

KW - NGF

KW - Osteoarthritis

KW - Pain

KW - Sensitization

UR - http://www.scopus.com/inward/record.url?scp=85103384668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85103384668&partnerID=8YFLogxK

U2 - 10.1016/j.rdc.2020.12.002

DO - 10.1016/j.rdc.2020.12.002

M3 - Review article

C2 - 33781488

AN - SCOPUS:85103384668

SN - 0889-857X

VL - 47

SP - 165

EP - 180

JO - Rheumatic Disease Clinics of North America

JF - Rheumatic Disease Clinics of North America

IS - 2

ER -

Basic Mechanisms of Pain in Osteoarthritis: Experimental Observations and New Perspectives

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this