The basicities of peptide bonds formed from various amino acids were investigated using anhydrous formic acid as a solvent probe. Conductivity measurements of the degree of protonation by formic acid gave the order of decreasing carbonyl basicity as: proline peptide bonds > serine > glycine ~ alanine. The peculiar position occupied by proline was established and discussed in terms of recent conformational analysis and solvent- polymer interaction.
ASJC Scopus subject areas
- Colloid and Surface Chemistry