Basophils and type 2 immunity

Booki Min, William E. Paul*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations

Abstract

PURPOSE OF REVIEW: Mechanisms involved in the development of in-vivo type 2 immunity are poorly defined. Basophils are potent IL-4-producing cells and may contribute to the process of polarizing immune responses. RECENT FINDINGS: Although basophils represent fewer than 0.5% of blood leukocytes, their frequency dramatically increases under certain circumstances, particularly Th2-related responses including parasitic infection and allergic inflammation. Recent studies proposed the hypothesis that basophils could contribute to the development of type 2 immunity by providing initial IL-4 important in T cell polarization and by recruiting other effector cells such as eosinophils or neutrophils. Multiple stimuli of IgE-dependent and IgE-independent pathways that lead to release of cytokines and mediators from activated basophils have been identified. In addition, progenitors that differentiate into mature basophils have recently been identified. SUMMARY: The current review revisits basophils with the goal of providing insights into understanding unappreciated roles of basophils in vivo.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalCurrent opinion in hematology
Volume15
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Keywords

  • Basophils
  • IL-4
  • Parasites
  • Th2 type immunity

ASJC Scopus subject areas

  • Hematology

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