Ba2+ current oscillation evoked by bradykinin in ras-transformed fibroblasts

Haruhiro Higashida*, Naoto Hoshi, Minako Hashii, Tao Fu, Mami Noda, Yoshinori Nozawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


By voltage-clamp recording, we show a novel inward current which oscillates after activation with bradykinin or serum in v-Ki-ras-transformed NIH 3T3 cells. The current oscillation was infrequently observed in control NIH 3T3 fibroblasts. The same stimulation evokes Ca2+ oscillations in the ras-transformed cells but not in parental cells (Fu et al., FEBS Lett. 281, 263-266, 1991). The results suggest that the oscillatory currents are generated by influxes of divalent cations to maintain Ca2+ oscillations in ras-transformed NIH 3T3 cells.

Original languageEnglish (US)
Pages (from-to)713-717
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Jul 31 1991

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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