Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat

Amay J. Bandodkar, Philipp Gutruf, Jungil Choi, Kun Hyuck Lee, Yurina Sekine, Jonathan T. Reeder, William J. Jeang, Alexander J. Aranyosi, Stephen P. Lee, Jeffrey B. Model, Roozbeh Ghaffari, Chun Ju Su, John P. Leshock, Tyler Ray, Anthony Verrillo, Kyle Thomas, Vaishnavi Krishnamurthi, Seungyong Han, Jeonghyun Kim, Siddharth Krishnan & 2 others Tao Hang, John A Rogers

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Wearable sweat sensors rely either on electronics for electrochemical detection or on colorimetry for visual readout. Non-ideal form factors represent disadvantages of the former, while semiquantitative operation and narrow scope of measurable biomarkers characterize the latter. Here, we introduce a battery-free, wireless electronic sensing platform inspired by biofuel cells that integrates chronometric microfluidic platforms with embedded colorimetric assays. The resulting sensors combine advantages of electronic and microfluidic functionality in a platform that is significantly lighter, cheaper, and smaller than alternatives. A demonstration device simultaneously monitors sweat rate/loss, pH, lactate, glucose, and chloride. Systematic studies of the electronics, microfluidics, and integration schemes establish the key design considerations and performance attributes. Two-day human trials that compare concentrations of glucose and lactate in sweat and blood suggest a potential basis for noninvasive, semi-quantitative tracking of physiological status.

Original languageEnglish (US)
Article numbereaav3294
JournalScience Advances
Volume5
Issue number1
DOIs
StatePublished - Jan 18 2019

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Colorimetric analysis
Volumetric analysis
Microfluidics
Skin
Lactic Acid
Electronic equipment
Biological fuel cells
Colorimetry
Glucose
Biomarkers
Chlorides
Fuel cells
Assays
Blood
Demonstrations
Sensors

ASJC Scopus subject areas

  • General

Cite this

Bandodkar, Amay J. ; Gutruf, Philipp ; Choi, Jungil ; Lee, Kun Hyuck ; Sekine, Yurina ; Reeder, Jonathan T. ; Jeang, William J. ; Aranyosi, Alexander J. ; Lee, Stephen P. ; Model, Jeffrey B. ; Ghaffari, Roozbeh ; Su, Chun Ju ; Leshock, John P. ; Ray, Tyler ; Verrillo, Anthony ; Thomas, Kyle ; Krishnamurthi, Vaishnavi ; Han, Seungyong ; Kim, Jeonghyun ; Krishnan, Siddharth ; Hang, Tao ; Rogers, John A. / Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat. In: Science Advances. 2019 ; Vol. 5, No. 1.
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abstract = "Wearable sweat sensors rely either on electronics for electrochemical detection or on colorimetry for visual readout. Non-ideal form factors represent disadvantages of the former, while semiquantitative operation and narrow scope of measurable biomarkers characterize the latter. Here, we introduce a battery-free, wireless electronic sensing platform inspired by biofuel cells that integrates chronometric microfluidic platforms with embedded colorimetric assays. The resulting sensors combine advantages of electronic and microfluidic functionality in a platform that is significantly lighter, cheaper, and smaller than alternatives. A demonstration device simultaneously monitors sweat rate/loss, pH, lactate, glucose, and chloride. Systematic studies of the electronics, microfluidics, and integration schemes establish the key design considerations and performance attributes. Two-day human trials that compare concentrations of glucose and lactate in sweat and blood suggest a potential basis for noninvasive, semi-quantitative tracking of physiological status.",
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Bandodkar, AJ, Gutruf, P, Choi, J, Lee, KH, Sekine, Y, Reeder, JT, Jeang, WJ, Aranyosi, AJ, Lee, SP, Model, JB, Ghaffari, R, Su, CJ, Leshock, JP, Ray, T, Verrillo, A, Thomas, K, Krishnamurthi, V, Han, S, Kim, J, Krishnan, S, Hang, T & Rogers, JA 2019, 'Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat', Science Advances, vol. 5, no. 1, eaav3294. https://doi.org/10.1126/sciadv.aav3294

Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat. / Bandodkar, Amay J.; Gutruf, Philipp; Choi, Jungil; Lee, Kun Hyuck; Sekine, Yurina; Reeder, Jonathan T.; Jeang, William J.; Aranyosi, Alexander J.; Lee, Stephen P.; Model, Jeffrey B.; Ghaffari, Roozbeh; Su, Chun Ju; Leshock, John P.; Ray, Tyler; Verrillo, Anthony; Thomas, Kyle; Krishnamurthi, Vaishnavi; Han, Seungyong; Kim, Jeonghyun; Krishnan, Siddharth; Hang, Tao; Rogers, John A.

In: Science Advances, Vol. 5, No. 1, eaav3294, 18.01.2019.

Research output: Contribution to journalArticle

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T1 - Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat

AU - Bandodkar, Amay J.

AU - Gutruf, Philipp

AU - Choi, Jungil

AU - Lee, Kun Hyuck

AU - Sekine, Yurina

AU - Reeder, Jonathan T.

AU - Jeang, William J.

AU - Aranyosi, Alexander J.

AU - Lee, Stephen P.

AU - Model, Jeffrey B.

AU - Ghaffari, Roozbeh

AU - Su, Chun Ju

AU - Leshock, John P.

AU - Ray, Tyler

AU - Verrillo, Anthony

AU - Thomas, Kyle

AU - Krishnamurthi, Vaishnavi

AU - Han, Seungyong

AU - Kim, Jeonghyun

AU - Krishnan, Siddharth

AU - Hang, Tao

AU - Rogers, John A

PY - 2019/1/18

Y1 - 2019/1/18

N2 - Wearable sweat sensors rely either on electronics for electrochemical detection or on colorimetry for visual readout. Non-ideal form factors represent disadvantages of the former, while semiquantitative operation and narrow scope of measurable biomarkers characterize the latter. Here, we introduce a battery-free, wireless electronic sensing platform inspired by biofuel cells that integrates chronometric microfluidic platforms with embedded colorimetric assays. The resulting sensors combine advantages of electronic and microfluidic functionality in a platform that is significantly lighter, cheaper, and smaller than alternatives. A demonstration device simultaneously monitors sweat rate/loss, pH, lactate, glucose, and chloride. Systematic studies of the electronics, microfluidics, and integration schemes establish the key design considerations and performance attributes. Two-day human trials that compare concentrations of glucose and lactate in sweat and blood suggest a potential basis for noninvasive, semi-quantitative tracking of physiological status.

AB - Wearable sweat sensors rely either on electronics for electrochemical detection or on colorimetry for visual readout. Non-ideal form factors represent disadvantages of the former, while semiquantitative operation and narrow scope of measurable biomarkers characterize the latter. Here, we introduce a battery-free, wireless electronic sensing platform inspired by biofuel cells that integrates chronometric microfluidic platforms with embedded colorimetric assays. The resulting sensors combine advantages of electronic and microfluidic functionality in a platform that is significantly lighter, cheaper, and smaller than alternatives. A demonstration device simultaneously monitors sweat rate/loss, pH, lactate, glucose, and chloride. Systematic studies of the electronics, microfluidics, and integration schemes establish the key design considerations and performance attributes. Two-day human trials that compare concentrations of glucose and lactate in sweat and blood suggest a potential basis for noninvasive, semi-quantitative tracking of physiological status.

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U2 - 10.1126/sciadv.aav3294

DO - 10.1126/sciadv.aav3294

M3 - Article

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JF - Science advances

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