@article{7da620cd45f247749ee851e21678c65e,
title = "BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update",
abstract = "There have been major advances in the armamentarium for hepatocellular carcinoma (HCC) since the last official update of the Barcelona Clinic Liver Cancer prognosis and treatment strategy published in 2018. Whilst there have been advances in all areas, we will focus on those that have led to a change in strategy and we will discuss why, despite being encouraging, data for select interventions are still too immature for them to be incorporated into an evidence-based model for clinicians and researchers. Finally, we describe the critical insight and expert knowledge that are required to make clinical decisions for individual patients, considering all of the parameters that must be considered to deliver personalised clinical management.",
keywords = "ablation, AFP, ALBI score, BCLC, HCC, liver transplantation TACE, surgery, survival, systemic treatment, TARE",
author = "Maria Reig and Alejandro Forner and Jordi Rimola and Joana Ferrer-F{\`a}brega and Marta Burrel and {\'A}ngeles Garcia-Criado and Kelley, {Robin K.} and Galle, {Peter R.} and Vincenzo Mazzaferro and Riad Salem and Bruno Sangro and Singal, {Amit G.} and Arndt Vogel and Josep Fuster and Carmen Ayuso and Jordi Bruix",
note = "Funding Information: MR: Dr. Reig{\textquoteright}s research is partially supported by Instituto de Salud Carlos III ( PI15/00145 and PI18/0358 ) and from the Spanish Health Ministry (National Strategic Plan against Hepatitis C). AF: Dr. Forner{\textquoteright}s research is partially supported by Instituto de Salud Carlos III ( PI13/01229 and PI18/00542 ). JR: Dr. Rimola{\textquoteright}s research is partially supported by grant from European Association for the Study of the Liver (EASL) . BS: Dr. Sangro{\textquoteright}s research is partially supported by ISCIII/EU TRANSCAN-2 ( AC16/00065 ), and Instituto de Salud Carlos III ( PI19/00742 ). AS: Dr. Singal{\textquoteright}s research is supported by National Institute of Health R01 R01 MD012565 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. JB: Dr. Bruix{\textquoteright}s research is partially supported by Instituto de Salud Carlos III ( PI18/00768 ), the Spanish Health Ministry (National Strategic Plan against Hepatitis C) and AECC ( PI044031 ). CIBERehd: is funded by the Instituto de Salud Carlos III . Dr. Rimola, Dr. Reig and Dr. Bruix are partially funded from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under grant agreement No 952103. Funding Information: MR: reports consultancy from Bayer, BMS, Roche, Ipsen, Astra Zeneca, Boston Science and Lilly; lecture fees from Bayer, BMS, Gilead, Lilly,Roche and UniversalDX and travel support from Bayer, BMS, Lilly and Astra Zeneca. Received research funding (to institution) from Bayer and Ipsen. AF: reports lecture fees from Bayer, Boston Science, Gilead, and MSD, consultancy fees from Bayer, Astra Zeneca, Roche, SIRTEX, AB Exact Science and Guerbert. JR: reports lectures and travel grants from Bayer and Roche. JFF: reports lecture fees from Bayer. MB: reports lectures and/or travel support from Boston Science, Terumo, Guerbet and Bayer. AGC: reports lectures fee from Boston Science, Terumo. KRK: reports consultancy fees (to self) from Exact Sciences, Genentech/Roche, Gilead. Received travel support from Ipsen. Received research funding (to institution) from Agios, Astra Zeneca, Bayer, BMS, Eli Lilly, EMD Serono, Exelixis, Genentech/Roche, Merck, Novartis, Partner Therapeutics, QED, Relay Therapeutics, Surface Oncology, Taiho. PRG: consultancy fees and/or travel support from Bayer, Boston Scientific, AstraZeneca, Adaptimmune, BMS, MSD, Sirtex, Lilly, Roche, Guerbet, Ipsen, Eisai. VM: Nothing to disclose. RS: reports consultancy fees from Boston Scientific, Cook, Bard, Genentech, Astrazeneca, Eisai, Sirtex, Siemens, research support from Boston Scientific. BS: reports consultancy fees from Adaptimmune, Astra Zeneca, Bayer, BMS, Boston Scientific, BTG, Eisai, Eli Lilly, H3 Biomedicine, Ipsen, Novartis, Merck, Roche, Sirtex Medical, Terumo; speaker fees from Astra Zeneca, Bayer, BMS, BTG, Eli Lilly, Ipsen, Novartis, Merck, Roche, Sirtex Medical, Terumo; research grants (to Institution) from BMS and Sirtex Medical. AS: has served on advisory boards or consulted for Genentech, Bayer, Eisai, AstraZeneca, BMS, and Exelixis. AV: Speaker, consultancy and advisory role: Amgen, Roche, Bayer, Sanofi, BMS, Lilly, Novartis, EISAI, AstraZeneca, Merck, Incyte, Ipsen, PierreFabre, MSD, Sirtex, BTG, Servier, Terumo, GSK. JFu: Nothing to disclose. CA: reports lectures fee from Bayer. JB: has consulted for Arqule, Bayer-Shering Pharma, Novartis, BMS, BTG- Biocompatibles, Eisai, Kowa, Terumo, Gilead, Bio-Alliance, Roche, AbbVie, MSD, Sirtex, Ipsen, Astra-Medimmune, Incyte, Quirem, Adaptimmune, Lilly, Basilea, Nerviano, Sanofi and UniversalDX; and received research/educational grants from Bayer, and lecture fees from Bayer-Shering Pharma, BTG-Biocompatibles, Eisai, Terumo, Sirtex, Ipsen. Funding Information: MR: Dr. Reig's research is partially supported by Instituto de Salud Carlos III (PI15/00145 and PI18/0358) and from the Spanish Health Ministry (National Strategic Plan against Hepatitis C). AF: Dr. Forner's research is partially supported by Instituto de Salud Carlos III (PI13/01229 and PI18/00542). JR: Dr. Rimola's research is partially supported by grant from European Association for the Study of the Liver (EASL). BS: Dr. Sangro's research is partially supported by ISCIII/EU TRANSCAN-2 (AC16/00065), and Instituto de Salud Carlos III (PI19/00742). AS: Dr. Singal's research is supported by National Institute of Health R01 R01 MD012565. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. JB: Dr. Bruix's research is partially supported by Instituto de Salud Carlos III (PI18/00768), the Spanish Health Ministry (National Strategic Plan against Hepatitis C) and AECC (PI044031). CIBERehd: is funded by the Instituto de Salud Carlos III. Dr. Rimola, Dr. Reig and Dr. Bruix are partially funded from the European Union's Horizon 2020 research and innovation programme under grant agreement No 952103. Publisher Copyright: {\textcopyright} 2021 European Association for the Study of the Liver",
year = "2022",
month = mar,
doi = "10.1016/j.jhep.2021.11.018",
language = "English (US)",
volume = "76",
pages = "681--693",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "3",
}
