Behavioral and electrophysiological effects of pallidal GABAB receptor activation and blockade on haloperidol-induced akinesia in rats

Lei Chen; Hong Tao Wang; Xiao Hua Han; Yu Lian Li; Qiao Ling Cui; Jun Xia Xie

doi:10.1016/j.brainres.2008.09.079

Behavioral and electrophysiological effects of pallidal GABA_B receptor activation and blockade on haloperidol-induced akinesia in rats

Lei Chen^*, Hong Tao Wang, Xiao Hua Han, Yu Lian Li, Qiao Ling Cui, Jun Xia Xie

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The globus pallidus plays an important role in movement regulation. Morphological studies have revealed GABA_B receptor expression in the globus pallidus. To investigate the behavioral and electrophysiological effects of pallidal GABA_B receptors on haloperidol-induced akinesia, microinjection and extracellular recordings were performed in the present study. Unilateral microinjection of GABA_B receptor agonist, baclofen, into globus pallidus produced ipsilateral dystonic posturing in haloperidol-induced akinesia rats. However, microinjection of GABA_B receptor antagonist, CGP55845, induced contralateral dystonic posturing, suggesting the tonic activity of pallidal GABAergic neurotransmission. Micro-pressure ejection of baclofen into globus pallidus decreased the spontaneous firing of pallidal neurons. Furthermore, local administration of CGP55845 alone induced a weak but consistent increase in the frequency of pallidal firing. The presence of CGP55845 prevented baclofen-induced effects completely. From the present in vivo findings it may be concluded that pallidal GABA_B receptors may contribute to the therapy of parkinsonian akinesia by modulating the activity of globus pallidus.

Original language	English (US)
Pages (from-to)	65-70
Number of pages	6
Journal	Brain research
Volume	1244
DOIs	https://doi.org/10.1016/j.brainres.2008.09.079
State	Published - Dec 9 2008
Externally published	Yes

Funding

This work was supported by the grant from the National Natural Science Foundation of China (30870800 and 30670664) and Natural Science Foundation of Shandong Province (Y2006C18).

Keywords

Baclofen
CGP55845
Globus pallidus
Single unit recording

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

Access to Document

10.1016/j.brainres.2008.09.079

Cite this

@article{95b08869f3c4464391be8b254f0dfae0,

title = "Behavioral and electrophysiological effects of pallidal GABAB receptor activation and blockade on haloperidol-induced akinesia in rats",

abstract = "The globus pallidus plays an important role in movement regulation. Morphological studies have revealed GABAB receptor expression in the globus pallidus. To investigate the behavioral and electrophysiological effects of pallidal GABAB receptors on haloperidol-induced akinesia, microinjection and extracellular recordings were performed in the present study. Unilateral microinjection of GABAB receptor agonist, baclofen, into globus pallidus produced ipsilateral dystonic posturing in haloperidol-induced akinesia rats. However, microinjection of GABAB receptor antagonist, CGP55845, induced contralateral dystonic posturing, suggesting the tonic activity of pallidal GABAergic neurotransmission. Micro-pressure ejection of baclofen into globus pallidus decreased the spontaneous firing of pallidal neurons. Furthermore, local administration of CGP55845 alone induced a weak but consistent increase in the frequency of pallidal firing. The presence of CGP55845 prevented baclofen-induced effects completely. From the present in vivo findings it may be concluded that pallidal GABAB receptors may contribute to the therapy of parkinsonian akinesia by modulating the activity of globus pallidus.",

keywords = "Baclofen, CGP55845, Globus pallidus, Single unit recording",

author = "Lei Chen and Wang, {Hong Tao} and Han, {Xiao Hua} and Li, {Yu Lian} and Cui, {Qiao Ling} and Xie, {Jun Xia}",

note = "Funding Information: This work was supported by the grant from the National Natural Science Foundation of China (30870800 and 30670664) and Natural Science Foundation of Shandong Province (Y2006C18). Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",

year = "2008",

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doi = "10.1016/j.brainres.2008.09.079",

language = "English (US)",

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T1 - Behavioral and electrophysiological effects of pallidal GABAB receptor activation and blockade on haloperidol-induced akinesia in rats

AU - Chen, Lei

AU - Wang, Hong Tao

AU - Han, Xiao Hua

AU - Li, Yu Lian

AU - Cui, Qiao Ling

AU - Xie, Jun Xia

N1 - Funding Information: This work was supported by the grant from the National Natural Science Foundation of China (30870800 and 30670664) and Natural Science Foundation of Shandong Province (Y2006C18). Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2008/12/9

Y1 - 2008/12/9

N2 - The globus pallidus plays an important role in movement regulation. Morphological studies have revealed GABAB receptor expression in the globus pallidus. To investigate the behavioral and electrophysiological effects of pallidal GABAB receptors on haloperidol-induced akinesia, microinjection and extracellular recordings were performed in the present study. Unilateral microinjection of GABAB receptor agonist, baclofen, into globus pallidus produced ipsilateral dystonic posturing in haloperidol-induced akinesia rats. However, microinjection of GABAB receptor antagonist, CGP55845, induced contralateral dystonic posturing, suggesting the tonic activity of pallidal GABAergic neurotransmission. Micro-pressure ejection of baclofen into globus pallidus decreased the spontaneous firing of pallidal neurons. Furthermore, local administration of CGP55845 alone induced a weak but consistent increase in the frequency of pallidal firing. The presence of CGP55845 prevented baclofen-induced effects completely. From the present in vivo findings it may be concluded that pallidal GABAB receptors may contribute to the therapy of parkinsonian akinesia by modulating the activity of globus pallidus.

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