Behavioral and electrophysiological effects of pallidal GABAB receptor activation and blockade on haloperidol-induced akinesia in rats

Lei Chen*, Hong Tao Wang, Xiao Hua Han, Yu Lian Li, Qiao Ling Cui, Jun Xia Xie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The globus pallidus plays an important role in movement regulation. Morphological studies have revealed GABAB receptor expression in the globus pallidus. To investigate the behavioral and electrophysiological effects of pallidal GABAB receptors on haloperidol-induced akinesia, microinjection and extracellular recordings were performed in the present study. Unilateral microinjection of GABAB receptor agonist, baclofen, into globus pallidus produced ipsilateral dystonic posturing in haloperidol-induced akinesia rats. However, microinjection of GABAB receptor antagonist, CGP55845, induced contralateral dystonic posturing, suggesting the tonic activity of pallidal GABAergic neurotransmission. Micro-pressure ejection of baclofen into globus pallidus decreased the spontaneous firing of pallidal neurons. Furthermore, local administration of CGP55845 alone induced a weak but consistent increase in the frequency of pallidal firing. The presence of CGP55845 prevented baclofen-induced effects completely. From the present in vivo findings it may be concluded that pallidal GABAB receptors may contribute to the therapy of parkinsonian akinesia by modulating the activity of globus pallidus.

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalBrain research
Volume1244
DOIs
StatePublished - Dec 9 2008
Externally publishedYes

Keywords

  • Baclofen
  • CGP55845
  • Globus pallidus
  • Single unit recording

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Behavioral and electrophysiological effects of pallidal GABA<sub>B</sub> receptor activation and blockade on haloperidol-induced akinesia in rats'. Together they form a unique fingerprint.

Cite this