Behavioral and trigeminal neuronal effects of rat brainstem-nanoinjected opiates

Lang Yan Xia; Kun Hou Huang; J. Peter Rosenfeld

doi:10.1016/0031-9384(92)90434-4

Behavioral and trigeminal neuronal effects of rat brainstem-nanoinjected opiates

Lang Yan Xia, Kun Hou Huang, J. Peter Rosenfeld^*

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Single injections of Met-enkephalin (ME; 27 rats) and artificial cerebrospinal fluid (ACF; 9 rats) in nucleus reticularis paragigantocellularis (PGC) and periaqueductal gray (PAG), and simultaneous conjoint PAG + PGC injections were made, and effects on facial responsiveness and caudal-trigeminal nuclear neuronal activity studied. It was found that all ME injections depressed the evoked excitatory neuronal and behavioral responses to noxious stimulation. Conjoint injections had apparently additive effects in comparison to single injection effects. Neither conjoint nor single injections had systematic effects on spontaneous neuronal activity. The ACF had no effects on any neuronal or behavioral activity.

Original language	English (US)
Pages (from-to)	65-73
Number of pages	9
Journal	Physiology and Behavior
Volume	52
Issue number	1
DOIs	https://doi.org/10.1016/0031-9384(92)90434-4
State	Published - Jul 1992

Funding

Supported by NIDA grant DA06971-04. Requests for reprints should be addressed to J. Peter Rosenfeld.

Keywords

Enkephalins
Nucleus reticularis paragigantocellularis
Opiate analgesia
Pain
Periaqueductal gray
Trigeminal nucleus

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(92)90434-4

Cite this

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title = "Behavioral and trigeminal neuronal effects of rat brainstem-nanoinjected opiates",

abstract = "Single injections of Met-enkephalin (ME; 27 rats) and artificial cerebrospinal fluid (ACF; 9 rats) in nucleus reticularis paragigantocellularis (PGC) and periaqueductal gray (PAG), and simultaneous conjoint PAG + PGC injections were made, and effects on facial responsiveness and caudal-trigeminal nuclear neuronal activity studied. It was found that all ME injections depressed the evoked excitatory neuronal and behavioral responses to noxious stimulation. Conjoint injections had apparently additive effects in comparison to single injection effects. Neither conjoint nor single injections had systematic effects on spontaneous neuronal activity. The ACF had no effects on any neuronal or behavioral activity.",

keywords = "Enkephalins, Nucleus reticularis paragigantocellularis, Opiate analgesia, Pain, Periaqueductal gray, Trigeminal nucleus",

author = "Xia, {Lang Yan} and Huang, {Kun Hou} and Rosenfeld, {J. Peter}",

note = "Funding Information: Supported by NIDA grant DA06971-04. Requests for reprints should be addressed to J. Peter Rosenfeld.",

year = "1992",

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T1 - Behavioral and trigeminal neuronal effects of rat brainstem-nanoinjected opiates

AU - Xia, Lang Yan

AU - Huang, Kun Hou

AU - Rosenfeld, J. Peter

N1 - Funding Information: Supported by NIDA grant DA06971-04. Requests for reprints should be addressed to J. Peter Rosenfeld.

PY - 1992/7

Y1 - 1992/7

N2 - Single injections of Met-enkephalin (ME; 27 rats) and artificial cerebrospinal fluid (ACF; 9 rats) in nucleus reticularis paragigantocellularis (PGC) and periaqueductal gray (PAG), and simultaneous conjoint PAG + PGC injections were made, and effects on facial responsiveness and caudal-trigeminal nuclear neuronal activity studied. It was found that all ME injections depressed the evoked excitatory neuronal and behavioral responses to noxious stimulation. Conjoint injections had apparently additive effects in comparison to single injection effects. Neither conjoint nor single injections had systematic effects on spontaneous neuronal activity. The ACF had no effects on any neuronal or behavioral activity.

AB - Single injections of Met-enkephalin (ME; 27 rats) and artificial cerebrospinal fluid (ACF; 9 rats) in nucleus reticularis paragigantocellularis (PGC) and periaqueductal gray (PAG), and simultaneous conjoint PAG + PGC injections were made, and effects on facial responsiveness and caudal-trigeminal nuclear neuronal activity studied. It was found that all ME injections depressed the evoked excitatory neuronal and behavioral responses to noxious stimulation. Conjoint injections had apparently additive effects in comparison to single injection effects. Neither conjoint nor single injections had systematic effects on spontaneous neuronal activity. The ACF had no effects on any neuronal or behavioral activity.

KW - Enkephalins

KW - Nucleus reticularis paragigantocellularis

KW - Opiate analgesia

KW - Pain

KW - Periaqueductal gray

KW - Trigeminal nucleus

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Behavioral and trigeminal neuronal effects of rat brainstem-nanoinjected opiates

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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