Behavioral, hormonal and histological stress markers of anxiety-separation in postnatal rats are reduced by prepro-thyrotropin-releasing hormone 178-199

Christine E. Stahl, Eva Redei, Yun Wang, Cesario V. Borlongan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We investigated in the present study whether systemic injections of prepro-thyrotropin-releasing-hormone 178-199 (PPTRH 178-199) in postnatal 3-days old rat pups can provide ameliorative effects in a model of anxiety-separation disorder. The pups were individually separated from their mother and placed in a novel environment. PPTRH 178-199-treated animals started exploring the novel environment in a significantly shorter time and elicited significantly less distress vocalizations than control animals. PPTRH 178-199-treated animals also had markedly lower serum adrenocorticotropic hormone and corticosterone compared to control animals. Furthermore, we observed a significant increase in PPTRH 178-199 immunoreactive cell bodies in the hypothalamus of PPTRH 178-199-treated animals compared to controls, suggesting that the peptide crossed the blood-brain barrier. PPTRH 178-199 treatment can help to reduce behavioral and hormonal disturbances associated with anxiety-separation situations.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalNeuroscience Letters
Volume321
Issue number1-2
DOIs
StatePublished - Mar 15 2002

Keywords

  • Adrenocorticotropic hormone
  • Corticosterone
  • Corticotropin release-inhibiting factor
  • Exploratory activity
  • Paraventricular nucleus
  • Stress
  • Vocalizations

ASJC Scopus subject areas

  • Neuroscience(all)

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