Behavioral interventions may prolong remission in patients with inflammatory bowel disease

Laurie Keefer*, Jennifer L. Kiebles, Zoran Martinovich, Elyse Cohen, Alyssa Van Denburg, Terrence A. Barrett

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Inflammatory Bowel Diseases (IBDs) are chronic, relapsing and remitting gastrointestinal conditions with no known cure. Previous studies have linked behavioral factors, including stress and medication adherence, to relapse. Purpose: We sought to determine the effect of participation in a behavioral self-management program on incidence of flare within 12 months following behavioral intervention when compared to the natural history of flare incidence prior to program participation. Results: Results from a 2-level regression model indicated that those participants in the treatment group were 57% less likely to flare in the following 12 months (compared to 18% in the control group). The decline in "flare odds" was about 2 times greater in treatment versus controls (OR. = 0.52, t(34). = 2.07, p<0.05). Office visits, ER visits, and disease severity (all p<0.05) were identified as moderators of flare risk. Conclusions: We have demonstrated 1) a statistical model estimating the likelihood of flare rates in the 12 months following a behavioral intervention for IBD (compared to a control condition), and 2) that the introduction of a behavioral intervention can alter the natural course of a chronic, relapsing and remitting gastrointestinal condition such as IBD.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalBehaviour Research and Therapy
Volume49
Issue number3
DOIs
StatePublished - Mar 1 2011

Fingerprint

Inflammatory Bowel Diseases
Office Visits
Medication Adherence
Incidence
Statistical Models
Self Care
Natural History
Recurrence
Control Groups
Therapeutics

Keywords

  • Behavioral self-management
  • Crohn's disease
  • Hypnotherapy
  • IBD
  • Remission
  • Ulcerative colitis

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Keefer, Laurie ; Kiebles, Jennifer L. ; Martinovich, Zoran ; Cohen, Elyse ; Van Denburg, Alyssa ; Barrett, Terrence A. / Behavioral interventions may prolong remission in patients with inflammatory bowel disease. In: Behaviour Research and Therapy. 2011 ; Vol. 49, No. 3. pp. 145-150.
@article{e3832d1c69a34453b0f5bae5f776067d,
title = "Behavioral interventions may prolong remission in patients with inflammatory bowel disease",
abstract = "Inflammatory Bowel Diseases (IBDs) are chronic, relapsing and remitting gastrointestinal conditions with no known cure. Previous studies have linked behavioral factors, including stress and medication adherence, to relapse. Purpose: We sought to determine the effect of participation in a behavioral self-management program on incidence of flare within 12 months following behavioral intervention when compared to the natural history of flare incidence prior to program participation. Results: Results from a 2-level regression model indicated that those participants in the treatment group were 57{\%} less likely to flare in the following 12 months (compared to 18{\%} in the control group). The decline in {"}flare odds{"} was about 2 times greater in treatment versus controls (OR. = 0.52, t(34). = 2.07, p<0.05). Office visits, ER visits, and disease severity (all p<0.05) were identified as moderators of flare risk. Conclusions: We have demonstrated 1) a statistical model estimating the likelihood of flare rates in the 12 months following a behavioral intervention for IBD (compared to a control condition), and 2) that the introduction of a behavioral intervention can alter the natural course of a chronic, relapsing and remitting gastrointestinal condition such as IBD.",
keywords = "Behavioral self-management, Crohn's disease, Hypnotherapy, IBD, Remission, Ulcerative colitis",
author = "Laurie Keefer and Kiebles, {Jennifer L.} and Zoran Martinovich and Elyse Cohen and {Van Denburg}, Alyssa and Barrett, {Terrence A.}",
year = "2011",
month = "3",
day = "1",
doi = "10.1016/j.brat.2010.12.005",
language = "English (US)",
volume = "49",
pages = "145--150",
journal = "Behaviour Research and Therapy",
issn = "0005-7967",
publisher = "Elsevier Limited",
number = "3",

}

Behavioral interventions may prolong remission in patients with inflammatory bowel disease. / Keefer, Laurie; Kiebles, Jennifer L.; Martinovich, Zoran; Cohen, Elyse; Van Denburg, Alyssa; Barrett, Terrence A.

In: Behaviour Research and Therapy, Vol. 49, No. 3, 01.03.2011, p. 145-150.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Behavioral interventions may prolong remission in patients with inflammatory bowel disease

AU - Keefer, Laurie

AU - Kiebles, Jennifer L.

AU - Martinovich, Zoran

AU - Cohen, Elyse

AU - Van Denburg, Alyssa

AU - Barrett, Terrence A.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Inflammatory Bowel Diseases (IBDs) are chronic, relapsing and remitting gastrointestinal conditions with no known cure. Previous studies have linked behavioral factors, including stress and medication adherence, to relapse. Purpose: We sought to determine the effect of participation in a behavioral self-management program on incidence of flare within 12 months following behavioral intervention when compared to the natural history of flare incidence prior to program participation. Results: Results from a 2-level regression model indicated that those participants in the treatment group were 57% less likely to flare in the following 12 months (compared to 18% in the control group). The decline in "flare odds" was about 2 times greater in treatment versus controls (OR. = 0.52, t(34). = 2.07, p<0.05). Office visits, ER visits, and disease severity (all p<0.05) were identified as moderators of flare risk. Conclusions: We have demonstrated 1) a statistical model estimating the likelihood of flare rates in the 12 months following a behavioral intervention for IBD (compared to a control condition), and 2) that the introduction of a behavioral intervention can alter the natural course of a chronic, relapsing and remitting gastrointestinal condition such as IBD.

AB - Inflammatory Bowel Diseases (IBDs) are chronic, relapsing and remitting gastrointestinal conditions with no known cure. Previous studies have linked behavioral factors, including stress and medication adherence, to relapse. Purpose: We sought to determine the effect of participation in a behavioral self-management program on incidence of flare within 12 months following behavioral intervention when compared to the natural history of flare incidence prior to program participation. Results: Results from a 2-level regression model indicated that those participants in the treatment group were 57% less likely to flare in the following 12 months (compared to 18% in the control group). The decline in "flare odds" was about 2 times greater in treatment versus controls (OR. = 0.52, t(34). = 2.07, p<0.05). Office visits, ER visits, and disease severity (all p<0.05) were identified as moderators of flare risk. Conclusions: We have demonstrated 1) a statistical model estimating the likelihood of flare rates in the 12 months following a behavioral intervention for IBD (compared to a control condition), and 2) that the introduction of a behavioral intervention can alter the natural course of a chronic, relapsing and remitting gastrointestinal condition such as IBD.

KW - Behavioral self-management

KW - Crohn's disease

KW - Hypnotherapy

KW - IBD

KW - Remission

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=79951676944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951676944&partnerID=8YFLogxK

U2 - 10.1016/j.brat.2010.12.005

DO - 10.1016/j.brat.2010.12.005

M3 - Article

C2 - 21256475

AN - SCOPUS:79951676944

VL - 49

SP - 145

EP - 150

JO - Behaviour Research and Therapy

JF - Behaviour Research and Therapy

SN - 0005-7967

IS - 3

ER -