Abstract
Behavioral rating scales were developed for quantification of phenyclidine (PCP)-induced locomotor activity, stereotyped behavior and ataxia in rats. The dose-response relationship for PCP-induced locomotor activity was found to be an inverted U-shaped function over tha first 25 min after injection while over the last 30 min of the experiment the function was highly linear. A linear dose-response relationship was found for ratings of stereotyped behavior and ataxia throughout the 90 min period of observation. The ratings of these two behaviors were found to be closely parallel. The effects of PCP on locomotor activity were found to be greatest during those intervals when stereotyped behavior and ataxia were at moderate levels. Ratings of locomotor activity may be confounded by ataxia when PCP is administered alone or in combination with other drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-179 |
| Number of pages | 11 |
| Journal | European Journal of Pharmacology |
| Volume | 59 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - Nov 16 1979 |
Funding
The authors express their gratitude to Mr. Theodore Karrison and Ms. Mary-Dichtel for assistance with statistical analyses. This research was supported, in part, by USPHS DA 02081, USPHS MHCRC 30,938 and the State of Illinois Department of Mental Health and Developmental Disabilities. RGF is recipient of 5 T32 GM 07151 and HYM is recipient of USPHS RCSA MH 47,808.
Keywords
- Ataxia
- Behavior
- Locomotor activity
- Phencyclidine
- Stereotyped behavior
ASJC Scopus subject areas
- Pharmacology