Behavioral threshold, cochlear electrophysiology, and cochlear histology in kanamycin poisoned chinchillas

A. Ryan, P. Dallos, M. A. Cheatham

Research output: Contribution to journalArticle

Abstract

Pure tone thresholds of normal chinchillas were determined by the shock avoidance procedure. Animals were then given daily kanamycin injections until a shift in threshold was observed. Injections were then terminated, and the threshold shift was allowed to stabilize. Approximately 30 days after the completion of kanamycin treatment, the animals were prepared for electrophysiological data collection. Intracochlear differential electrodes were placed in the first cochlear turn of both ears. Cochlear microphonic, summating potential, and compound action potential responses were collected. Finally, animals were sacrificed and the ears were prepared for histological examination by the surface preparation technique. Correlations between behavioral, electrophysiological, and histological measures are discussed.

Original languageEnglish (US)
Pages (from-to)S78
Journaljournal of the Acoustical Society of America
Volume55
Issue numbersup
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Acoustics and Ultrasonics

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