Behaviorally Selective Engagement of Short-Latency Effector Pathways by Motor Cortex

Andrew Miri*, Claire L. Warriner, Jeffrey S. Seely, Gamaleldin F. Elsayed, John P. Cunningham, Mark M. Churchland, Thomas M. Jessell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Blocking motor cortical output with lesions or pharmacological inactivation has identified movements that require motor cortex. Yet, when and how motor cortex influences muscle activity during movement execution remains unresolved. We addressed this ambiguity using measurement and perturbation of motor cortical activity together with electromyography in mice during two forelimb movements that differ in their requirement for cortical involvement. Rapid optogenetic silencing and electrical stimulation indicated that short-latency pathways linking motor cortex with spinal motor neurons are selectively activated during one behavior. Analysis of motor cortical activity revealed a dramatic change between behaviors in the coordination of firing patterns across neurons that could account for this differential influence. Thus, our results suggest that changes in motor cortical output patterns enable a behaviorally selective engagement of short-latency effector pathways. The model of motor cortical influence implied by our findings helps reconcile previous observations on the function of motor cortex.

Original languageEnglish (US)
Pages (from-to)683-696.e11
JournalNeuron
Volume95
Issue number3
DOIs
StatePublished - Aug 2 2017

Keywords

  • channelrhodopsin
  • motor cortex
  • mouse
  • neural dynamics
  • neural recording

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Behaviorally Selective Engagement of Short-Latency Effector Pathways by Motor Cortex'. Together they form a unique fingerprint.

Cite this