Being overweight is associated with greater survival in ICU patients: Results from the intensive care over nations audit

Yasser Sakr, Ilmi Alhussami, Rahul Nanchal, Richard G. Wunderink, Tommaso Pellis, Xavier Wittebole, Ignacio Martin-Loeches, Bruno François, Marc Leone, Jean Louis Vincent*

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Objective: To assess the effect of body mass index on ICU outcome and on the development of ICU-acquired infection. Design: A substudy of the Intensive Care Over Nations audit. Setting: Seven hundred thirty ICUs in 84 countries. Patients: All adult ICU patients admitted between May 8 and 18, 2012, except those admitted for less than 24 hours for routine postoperative monitoring (n = 10,069). In this subanalysis, only patients with complete data on height and weight (measured or estimated) on ICU admission in order to calculate the body mass index were included (n = 8,829). Interventions: None. Measurements and Main Results: Underweight was defined as body mass index less than 18.5 kg/m2, normal weight as body mass index 18.5-24.9 kg/m2, overweight as body mass index 25-29.9 kg/m2, obese as body mass index 30-39.9 kg/m2, and morbidly obese as body mass index greater than or equal to 40 kg/m2. The mean body mass index was 26.4 ± 6.5 kg/m2. The ICU length of stay was similar among categories, but overweight and obese patients had longer hospital lengths of stay than patients with normal body mass index (10 [interquartile range, 5-21] and 11 [5-21] vs 9 [4-19] d; p < 0.01 pairwise). ICU mortality was lower in morbidly obese than in normal body mass index patients (11.2% vs 16.6%; p = 0.015). In-hospital mortality was lower in morbidly obese and overweight patients and higher in underweight patients than in those with normal body mass index. In a multilevel Cox proportional hazard analysis, underweight was independently associated with a higher hazard of 60-day in-hospital death (hazard ratio, 1.32; 95% CI, 1.05-1.65; p = 0.018), whereas overweight was associated with a lower hazard (hazard ratio, 0.79; 95% CI, 0.71-0.89; p < 0.001). No body mass index category was associated with an increased hazard of ICU-acquired infection. Conclusions: In this large cohort of critically ill patients, underweight was independently associated with a higher hazard of 60-day in-hospital death and overweight with a lower hazard. None of the body mass index categories as independently associated with an increased hazard of infection during the ICU stay.

Original languageEnglish (US)
Pages (from-to)2623-2632
Number of pages10
JournalCritical care medicine
Volume43
Issue number12
DOIs
StatePublished - Dec 1 2015

Keywords

  • body mass index
  • nosocomial infection
  • obesity
  • underweight

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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    Sakr, Y., Alhussami, I., Nanchal, R., Wunderink, R. G., Pellis, T., Wittebole, X., Martin-Loeches, I., François, B., Leone, M., & Vincent, J. L. (2015). Being overweight is associated with greater survival in ICU patients: Results from the intensive care over nations audit. Critical care medicine, 43(12), 2623-2632. https://doi.org/10.1097/CCM.0000000000001310