Abstract
X-Ray crystallography and dynamic 1H NMR spectroscopy have revealed that 1,4,5,8-tetramethyl-, 1-bromomethyl-4,5,8-trimethyl-, and 1,8-bis(bromomethyl)-4,5-dimethyl-2,3,6,7-tetrabromonaphthalene - 3, 4, and 5, respectively - have severely distorted naphthalene nuclei in the solid state that also correspond to the gross conformations that occupy appreciable (ΔG‡∼16 kcal mol-1) energy wells in the solution state.
Original language | English (US) |
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Pages (from-to) | 8333-8336 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 34 |
Issue number | 51 |
DOIs | |
State | Published - Dec 17 1993 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry