Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

Zhenyi An; Wei Chung Chiang; Álvaro F. Fernández; Luis H. Franco; Cong Cong He; Shu Yi Huang; Eunmyong Lee; Yang Liu; Salwa Sebti; Sanae Shoji-Kawata; Shyam Sirasanagandla; Richard C. Wang; Yongjie Wei; Yuting Zhao; Silvia Vega-Rubin-de-Celis

doi:10.3389/fcell.2022.891332

Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

Zhenyi An, Wei Chung Chiang, Álvaro F. Fernández, Luis H. Franco, Cong Cong He, Shu Yi Huang, Eunmyong Lee, Yang Liu, Salwa Sebti, Sanae Shoji-Kawata, Shyam Sirasanagandla, Richard C. Wang, Yongjie Wei, Yuting Zhao, Silvia Vega-Rubin-de-Celis^*

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.

Original language	English (US)
Article number	891332
Journal	Frontiers in Cell and Developmental Biology
Volume	10
DOIs	https://doi.org/10.3389/fcell.2022.891332
State	Published - Jun 27 2022

Keywords

BECN1
Beth Levine
aging
cancer
infectious diseases
macroautophagy
metabolism
selective autophagy

ASJC Scopus subject areas

Developmental Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fcell.2022.891332

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An, Z., Chiang, W. C., Fernández, Á. F., Franco, L. H., He, C. C., Huang, S. Y., Lee, E., Liu, Y., Sebti, S., Shoji-Kawata, S., Sirasanagandla, S., Wang, R. C., Wei, Y., Zhao, Y., & Vega-Rubin-de-Celis, S. (2022). Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective. Frontiers in Cell and Developmental Biology, 10, Article 891332. https://doi.org/10.3389/fcell.2022.891332

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title = "Beth Levine{\textquoteright}s Legacy: From the Discovery of BECN1 to Therapies. A Mentees{\textquoteright} Perspective",

abstract = "With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.",

keywords = "BECN1, Beth Levine, aging, cancer, infectious diseases, macroautophagy, metabolism, selective autophagy",

author = "Zhenyi An and Chiang, {Wei Chung} and Fern{\'a}ndez, {{\'A}lvaro F.} and Franco, {Luis H.} and He, {Cong Cong} and Huang, {Shu Yi} and Eunmyong Lee and Yang Liu and Salwa Sebti and Sanae Shoji-Kawata and Shyam Sirasanagandla and Wang, {Richard C.} and Yongjie Wei and Yuting Zhao and Silvia Vega-Rubin-de-Celis",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 An, Chiang, Fern{\'a}ndez, Franco, He, Huang, Lee, Liu, Sebti, Shoji-Kawata, Sirasanagandla, Wang, Wei, Zhao and Vega-Rubin-de-Celis.",

year = "2022",

month = jun,

day = "27",

doi = "10.3389/fcell.2022.891332",

language = "English (US)",

volume = "10",

journal = "Frontiers in Cell and Developmental Biology",

issn = "2296-634X",

publisher = "Frontiers Media SA",

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An, Z, Chiang, WC, Fernández, ÁF, Franco, LH, He, CC, Huang, SY, Lee, E, Liu, Y, Sebti, S, Shoji-Kawata, S, Sirasanagandla, S, Wang, RC, Wei, Y, Zhao, Y & Vega-Rubin-de-Celis, S 2022, 'Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective', Frontiers in Cell and Developmental Biology, vol. 10, 891332. https://doi.org/10.3389/fcell.2022.891332

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T2 - From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

AU - An, Zhenyi

AU - Chiang, Wei Chung

AU - Fernández, Álvaro F.

AU - Franco, Luis H.

AU - He, Cong Cong

AU - Huang, Shu Yi

AU - Lee, Eunmyong

AU - Liu, Yang

AU - Sebti, Salwa

AU - Shoji-Kawata, Sanae

AU - Sirasanagandla, Shyam

AU - Wang, Richard C.

AU - Wei, Yongjie

AU - Zhao, Yuting

AU - Vega-Rubin-de-Celis, Silvia

PY - 2022/6/27

Y1 - 2022/6/27

N2 - With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.

AB - With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.

KW - BECN1

KW - Beth Levine

KW - aging

KW - cancer

KW - infectious diseases

KW - macroautophagy

KW - metabolism

KW - selective autophagy

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Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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