Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

Zhenyi An, Wei Chung Chiang, Álvaro F. Fernández, Luis H. Franco, Cong Cong He, Shu Yi Huang, Eunmyong Lee, Yang Liu, Salwa Sebti, Sanae Shoji-Kawata, Shyam Sirasanagandla, Richard C. Wang, Yongjie Wei, Yuting Zhao, Silvia Vega-Rubin-de-Celis*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.

Original languageEnglish (US)
Article number891332
JournalFrontiers in Cell and Developmental Biology
StatePublished - Jun 27 2022


  • BECN1
  • Beth Levine
  • aging
  • cancer
  • infectious diseases
  • macroautophagy
  • metabolism
  • selective autophagy

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology


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