Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease - Perspectives from the CREDO-Kyoto Registry

Yutaka Furukawa*, Ryoji Taniguchi, Natsuhiko Ehara, Neiko Ozasa, Yoshisumi Haruna, Naritatsu Saito, Takahiro Doi, Kozo Hoshino, Satoshi Shizuta, Takeshi Morimoto, Yukiko Imai, Satoshi Teramukai, Masanori Fukushima, Toru Kita, Takeshi Kimura, Jong Dae Lee, Kuniyoshi Tanaka, Katsuo Okazaki, Masaaki Takahashi, Teiji OdaShigeo Matsui, Naohiro Ohashi, Eiichi Matsuyama, Makoto Kadoya, Yoshiki Takatsu, Shinichi Nomoto, Kazuaki Kataoka, Hajime Kotoura, Masaki Aota, Akira Miura, Satoru Suwa, Chuwa Tei, Ryuzo Sakata, Shuichi Hamasaki, Hiroyuki Yamamoto, Takeshi Aoyama, Takahiro Sakurai, Mitsuo Matsuda, Masahiko Onoe, Yuzo Takeuchi, Ryuji Nohara, Kimisato Nakano, Shigefumi Morioka, Yukikatsu Okada, Kenichi Shiratori, Yasuki Kihara, Michihiro Nasu, Masakiyo Nobuyoshi, Hitoshi Okabayashi, Hitoshi Yasumoto, Jyota Nakano, Tomoyuki Murakami, Katsuya Ishida, Hisao Ogawa, Michio Kawasuji, Seigo Sugiyama, Shoichiro Hagiwara, Kazuaki Mitsudo, Tatsuhiko Komiya, Kazushige Kadota, Masashi Komeda, Ryozo Tatami, Teruaki Ushijima, Akira Yoshida, Hiroyuki Nakajima, Shinji Miki, Ryuichi Hattori, Noboru Nishiwaki, Manabu Shirotani, Hiroshi Kato, Hiroshi Eizawa, Masaru Tanaka, Kazuaki Minami, Minoru Horie, Tohru Asai, Hiroyuki Takashima, Ryuji Higashita, Mamoru Takahashi, Takafumi Tahata, Yoshiki Matoba, Kiyoshi Doyama, Makoto Araki, Akinori Takizawa, Mitsuomi Shimamoto, Fumio Yamazaki, Osamu Doi, Hirofumi Kambara, Katsuhiko Matsuda, Satoshi Kaburagi, Masafumi Nara, Masaki Kawanami, Takashi Konishi, Kazunobu Nishimura, Seiji Ootani, Takaaki Sugita

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Background: The importance of statins in cardiovascular prevention has been demonstrated in various patient subsets. This study aimed to evaluate the effects of statins on long-term outcomes of Japanese patients undergoing their first coronary revascularization. Methods and Results: A total of 9,225 patients undergoing their first coronary revascularizations during 2000-2002 were divided into 2 groups according to the use of statins at discharge; patients with acute myocardial infarction were not included. Statins was administered to only 28.5% (n=2,630) of the patients. The median follow-up period was 3.5 years. Patients on statin therapy showed lower all-cause (5.2% vs 10.0%; p<0.0001) and cardiovascular (3.2% vs 6.2%; p<0.0001) mortality than those without statins (n=6,595) by Kaplan-Meier analysis and log-rank test. After adjustment by multivariate analysis according to 29 variables, statin therapy remained as an independent predictor of reduced all-cause (relative risk ratio (RR) 0.71, 95% confidence interval (CI) 0.59-0.86, p=0.0005) and cardiovascular (RR 0.72, 95% CI 0.56-0.91, p=0.0067) mortality. The validity of RR of statin therapy in multivariate analysis was further confirmed by risk adjustment using propensity scores (all-cause mortality: propensity-adjusted RR 0.70, 95% CI 0.58-0.85, p=0.0003; cardiovascular mortality: propensity-adjusted RR 0.70, 95% CI 0.54-0.89, p=0.0038). Conclusions: Statin therapy started at hospital discharge was associated with increased chance of survival in Japanese patients undergoing their first coronary revascularization.

Original languageEnglish (US)
Pages (from-to)1937-1945
Number of pages9
JournalCirculation Journal
Volume72
Issue number12
DOIs
StatePublished - Dec 3 2008

Keywords

  • Coronary artery disease
  • Mortality
  • Revascularization
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Furukawa, Y., Taniguchi, R., Ehara, N., Ozasa, N., Haruna, Y., Saito, N., Doi, T., Hoshino, K., Shizuta, S., Morimoto, T., Imai, Y., Teramukai, S., Fukushima, M., Kita, T., Kimura, T., Lee, J. D., Tanaka, K., Okazaki, K., Takahashi, M., ... Sugita, T. (2008). Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease - Perspectives from the CREDO-Kyoto Registry. Circulation Journal, 72(12), 1937-1945. https://doi.org/10.1253/circj.CJ-08-0293