Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease - Perspectives from the CREDO-Kyoto Registry

Yutaka Furukawa*, Ryoji Taniguchi, Natsuhiko Ehara, Neiko Ozasa, Yoshisumi Haruna, Naritatsu Saito, Takahiro Doi, Kozo Hoshino, Satoshi Shizuta, Takeshi Morimoto, Yukiko Imai, Satoshi Teramukai, Masanori Fukushima, Toru Kita, Takeshi Kimura, Jong Dae Lee, Kuniyoshi Tanaka, Katsuo Okazaki, Masaaki Takahashi, Teiji OdaShigeo Matsui, Naohiro Ohashi, Eiichi Matsuyama, Makoto Kadoya, Yoshiki Takatsu, Shinichi Nomoto, Kazuaki Kataoka, Hajime Kotoura, Masaki Aota, Akira Miura, Satoru Suwa, Chuwa Tei, Ryuzo Sakata, Shuichi Hamasaki, Hiroyuki Yamamoto, Takeshi Aoyama, Takahiro Sakurai, Mitsuo Matsuda, Masahiko Onoe, Yuzo Takeuchi, Ryuji Nohara, Kimisato Nakano, Shigefumi Morioka, Yukikatsu Okada, Kenichi Shiratori, Yasuki Kihara, Michihiro Nasu, Masakiyo Nobuyoshi, Hitoshi Okabayashi, Hitoshi Yasumoto, Jyota Nakano, Tomoyuki Murakami, Katsuya Ishida, Hisao Ogawa, Michio Kawasuji, Seigo Sugiyama, Shoichiro Hagiwara, Kazuaki Mitsudo, Tatsuhiko Komiya, Kazushige Kadota, Masashi Komeda, Ryozo Tatami, Teruaki Ushijima, Akira Yoshida, Hiroyuki Nakajima, Shinji Miki, Ryuichi Hattori, Noboru Nishiwaki, Manabu Shirotani, Hiroshi Kato, Hiroshi Eizawa, Masaru Tanaka, Kazuaki Minami, Minoru Horie, Tohru Asai, Hiroyuki Takashima, Ryuji Higashita, Mamoru Takahashi, Takafumi Tahata, Yoshiki Matoba, Kiyoshi Doyama, Makoto Araki, Akinori Takizawa, Mitsuomi Shimamoto, Fumio Yamazaki, Osamu Doi, Hirofumi Kambara, Katsuhiko Matsuda, Satoshi Kaburagi, Masafumi Nara, Masaki Kawanami, Takashi Konishi, Kazunobu Nishimura, Seiji Ootani, Takaaki Sugita

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: The importance of statins in cardiovascular prevention has been demonstrated in various patient subsets. This study aimed to evaluate the effects of statins on long-term outcomes of Japanese patients undergoing their first coronary revascularization. Methods and Results: A total of 9,225 patients undergoing their first coronary revascularizations during 2000-2002 were divided into 2 groups according to the use of statins at discharge; patients with acute myocardial infarction were not included. Statins was administered to only 28.5% (n=2,630) of the patients. The median follow-up period was 3.5 years. Patients on statin therapy showed lower all-cause (5.2% vs 10.0%; p<0.0001) and cardiovascular (3.2% vs 6.2%; p<0.0001) mortality than those without statins (n=6,595) by Kaplan-Meier analysis and log-rank test. After adjustment by multivariate analysis according to 29 variables, statin therapy remained as an independent predictor of reduced all-cause (relative risk ratio (RR) 0.71, 95% confidence interval (CI) 0.59-0.86, p=0.0005) and cardiovascular (RR 0.72, 95% CI 0.56-0.91, p=0.0067) mortality. The validity of RR of statin therapy in multivariate analysis was further confirmed by risk adjustment using propensity scores (all-cause mortality: propensity-adjusted RR 0.70, 95% CI 0.58-0.85, p=0.0003; cardiovascular mortality: propensity-adjusted RR 0.70, 95% CI 0.54-0.89, p=0.0038). Conclusions: Statin therapy started at hospital discharge was associated with increased chance of survival in Japanese patients undergoing their first coronary revascularization.

Original languageEnglish (US)
Pages (from-to)1937-1945
Number of pages9
JournalCirculation Journal
Volume72
Issue number12
DOIs
StatePublished - Dec 3 2008

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registries
Coronary Artery Disease
Survival
Odds Ratio
Confidence Intervals
Therapeutics
Mortality
Multivariate Analysis
Risk Adjustment
Propensity Score
Kaplan-Meier Estimate
Myocardial Infarction

Keywords

  • Coronary artery disease
  • Mortality
  • Revascularization
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Furukawa, Yutaka ; Taniguchi, Ryoji ; Ehara, Natsuhiko ; Ozasa, Neiko ; Haruna, Yoshisumi ; Saito, Naritatsu ; Doi, Takahiro ; Hoshino, Kozo ; Shizuta, Satoshi ; Morimoto, Takeshi ; Imai, Yukiko ; Teramukai, Satoshi ; Fukushima, Masanori ; Kita, Toru ; Kimura, Takeshi ; Lee, Jong Dae ; Tanaka, Kuniyoshi ; Okazaki, Katsuo ; Takahashi, Masaaki ; Oda, Teiji ; Matsui, Shigeo ; Ohashi, Naohiro ; Matsuyama, Eiichi ; Kadoya, Makoto ; Takatsu, Yoshiki ; Nomoto, Shinichi ; Kataoka, Kazuaki ; Kotoura, Hajime ; Aota, Masaki ; Miura, Akira ; Suwa, Satoru ; Tei, Chuwa ; Sakata, Ryuzo ; Hamasaki, Shuichi ; Yamamoto, Hiroyuki ; Aoyama, Takeshi ; Sakurai, Takahiro ; Matsuda, Mitsuo ; Onoe, Masahiko ; Takeuchi, Yuzo ; Nohara, Ryuji ; Nakano, Kimisato ; Morioka, Shigefumi ; Okada, Yukikatsu ; Shiratori, Kenichi ; Kihara, Yasuki ; Nasu, Michihiro ; Nobuyoshi, Masakiyo ; Okabayashi, Hitoshi ; Yasumoto, Hitoshi ; Nakano, Jyota ; Murakami, Tomoyuki ; Ishida, Katsuya ; Ogawa, Hisao ; Kawasuji, Michio ; Sugiyama, Seigo ; Hagiwara, Shoichiro ; Mitsudo, Kazuaki ; Komiya, Tatsuhiko ; Kadota, Kazushige ; Komeda, Masashi ; Tatami, Ryozo ; Ushijima, Teruaki ; Yoshida, Akira ; Nakajima, Hiroyuki ; Miki, Shinji ; Hattori, Ryuichi ; Nishiwaki, Noboru ; Shirotani, Manabu ; Kato, Hiroshi ; Eizawa, Hiroshi ; Tanaka, Masaru ; Minami, Kazuaki ; Horie, Minoru ; Asai, Tohru ; Takashima, Hiroyuki ; Higashita, Ryuji ; Takahashi, Mamoru ; Tahata, Takafumi ; Matoba, Yoshiki ; Doyama, Kiyoshi ; Araki, Makoto ; Takizawa, Akinori ; Shimamoto, Mitsuomi ; Yamazaki, Fumio ; Doi, Osamu ; Kambara, Hirofumi ; Matsuda, Katsuhiko ; Kaburagi, Satoshi ; Nara, Masafumi ; Kawanami, Masaki ; Konishi, Takashi ; Nishimura, Kazunobu ; Ootani, Seiji ; Sugita, Takaaki. / Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease - Perspectives from the CREDO-Kyoto Registry. In: Circulation Journal. 2008 ; Vol. 72, No. 12. pp. 1937-1945.
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title = "Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease - Perspectives from the CREDO-Kyoto Registry",
abstract = "Background: The importance of statins in cardiovascular prevention has been demonstrated in various patient subsets. This study aimed to evaluate the effects of statins on long-term outcomes of Japanese patients undergoing their first coronary revascularization. Methods and Results: A total of 9,225 patients undergoing their first coronary revascularizations during 2000-2002 were divided into 2 groups according to the use of statins at discharge; patients with acute myocardial infarction were not included. Statins was administered to only 28.5{\%} (n=2,630) of the patients. The median follow-up period was 3.5 years. Patients on statin therapy showed lower all-cause (5.2{\%} vs 10.0{\%}; p<0.0001) and cardiovascular (3.2{\%} vs 6.2{\%}; p<0.0001) mortality than those without statins (n=6,595) by Kaplan-Meier analysis and log-rank test. After adjustment by multivariate analysis according to 29 variables, statin therapy remained as an independent predictor of reduced all-cause (relative risk ratio (RR) 0.71, 95{\%} confidence interval (CI) 0.59-0.86, p=0.0005) and cardiovascular (RR 0.72, 95{\%} CI 0.56-0.91, p=0.0067) mortality. The validity of RR of statin therapy in multivariate analysis was further confirmed by risk adjustment using propensity scores (all-cause mortality: propensity-adjusted RR 0.70, 95{\%} CI 0.58-0.85, p=0.0003; cardiovascular mortality: propensity-adjusted RR 0.70, 95{\%} CI 0.54-0.89, p=0.0038). Conclusions: Statin therapy started at hospital discharge was associated with increased chance of survival in Japanese patients undergoing their first coronary revascularization.",
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author = "Yutaka Furukawa and Ryoji Taniguchi and Natsuhiko Ehara and Neiko Ozasa and Yoshisumi Haruna and Naritatsu Saito and Takahiro Doi and Kozo Hoshino and Satoshi Shizuta and Takeshi Morimoto and Yukiko Imai and Satoshi Teramukai and Masanori Fukushima and Toru Kita and Takeshi Kimura and Lee, {Jong Dae} and Kuniyoshi Tanaka and Katsuo Okazaki and Masaaki Takahashi and Teiji Oda and Shigeo Matsui and Naohiro Ohashi and Eiichi Matsuyama and Makoto Kadoya and Yoshiki Takatsu and Shinichi Nomoto and Kazuaki Kataoka and Hajime Kotoura and Masaki Aota and Akira Miura and Satoru Suwa and Chuwa Tei and Ryuzo Sakata and Shuichi Hamasaki and Hiroyuki Yamamoto and Takeshi Aoyama and Takahiro Sakurai and Mitsuo Matsuda and Masahiko Onoe and Yuzo Takeuchi and Ryuji Nohara and Kimisato Nakano and Shigefumi Morioka and Yukikatsu Okada and Kenichi Shiratori and Yasuki Kihara and Michihiro Nasu and Masakiyo Nobuyoshi and Hitoshi Okabayashi and Hitoshi Yasumoto and Jyota Nakano and Tomoyuki Murakami and Katsuya Ishida and Hisao Ogawa and Michio Kawasuji and Seigo Sugiyama and Shoichiro Hagiwara and Kazuaki Mitsudo and Tatsuhiko Komiya and Kazushige Kadota and Masashi Komeda and Ryozo Tatami and Teruaki Ushijima and Akira Yoshida and Hiroyuki Nakajima and Shinji Miki and Ryuichi Hattori and Noboru Nishiwaki and Manabu Shirotani and Hiroshi Kato and Hiroshi Eizawa and Masaru Tanaka and Kazuaki Minami and Minoru Horie and Tohru Asai and Hiroyuki Takashima and Ryuji Higashita and Mamoru Takahashi and Takafumi Tahata and Yoshiki Matoba and Kiyoshi Doyama and Makoto Araki and Akinori Takizawa and Mitsuomi Shimamoto and Fumio Yamazaki and Osamu Doi and Hirofumi Kambara and Katsuhiko Matsuda and Satoshi Kaburagi and Masafumi Nara and Masaki Kawanami and Takashi Konishi and Kazunobu Nishimura and Seiji Ootani and Takaaki Sugita",
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Furukawa, Y, Taniguchi, R, Ehara, N, Ozasa, N, Haruna, Y, Saito, N, Doi, T, Hoshino, K, Shizuta, S, Morimoto, T, Imai, Y, Teramukai, S, Fukushima, M, Kita, T, Kimura, T, Lee, JD, Tanaka, K, Okazaki, K, Takahashi, M, Oda, T, Matsui, S, Ohashi, N, Matsuyama, E, Kadoya, M, Takatsu, Y, Nomoto, S, Kataoka, K, Kotoura, H, Aota, M, Miura, A, Suwa, S, Tei, C, Sakata, R, Hamasaki, S, Yamamoto, H, Aoyama, T, Sakurai, T, Matsuda, M, Onoe, M, Takeuchi, Y, Nohara, R, Nakano, K, Morioka, S, Okada, Y, Shiratori, K, Kihara, Y, Nasu, M, Nobuyoshi, M, Okabayashi, H, Yasumoto, H, Nakano, J, Murakami, T, Ishida, K, Ogawa, H, Kawasuji, M, Sugiyama, S, Hagiwara, S, Mitsudo, K, Komiya, T, Kadota, K, Komeda, M, Tatami, R, Ushijima, T, Yoshida, A, Nakajima, H, Miki, S, Hattori, R, Nishiwaki, N, Shirotani, M, Kato, H, Eizawa, H, Tanaka, M, Minami, K, Horie, M, Asai, T, Takashima, H, Higashita, R, Takahashi, M, Tahata, T, Matoba, Y, Doyama, K, Araki, M, Takizawa, A, Shimamoto, M, Yamazaki, F, Doi, O, Kambara, H, Matsuda, K, Kaburagi, S, Nara, M, Kawanami, M, Konishi, T, Nishimura, K, Ootani, S & Sugita, T 2008, 'Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease - Perspectives from the CREDO-Kyoto Registry', Circulation Journal, vol. 72, no. 12, pp. 1937-1945. https://doi.org/10.1253/circj.CJ-08-0293

Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease - Perspectives from the CREDO-Kyoto Registry. / Furukawa, Yutaka; Taniguchi, Ryoji; Ehara, Natsuhiko; Ozasa, Neiko; Haruna, Yoshisumi; Saito, Naritatsu; Doi, Takahiro; Hoshino, Kozo; Shizuta, Satoshi; Morimoto, Takeshi; Imai, Yukiko; Teramukai, Satoshi; Fukushima, Masanori; Kita, Toru; Kimura, Takeshi; Lee, Jong Dae; Tanaka, Kuniyoshi; Okazaki, Katsuo; Takahashi, Masaaki; Oda, Teiji; Matsui, Shigeo; Ohashi, Naohiro; Matsuyama, Eiichi; Kadoya, Makoto; Takatsu, Yoshiki; Nomoto, Shinichi; Kataoka, Kazuaki; Kotoura, Hajime; Aota, Masaki; Miura, Akira; Suwa, Satoru; Tei, Chuwa; Sakata, Ryuzo; Hamasaki, Shuichi; Yamamoto, Hiroyuki; Aoyama, Takeshi; Sakurai, Takahiro; Matsuda, Mitsuo; Onoe, Masahiko; Takeuchi, Yuzo; Nohara, Ryuji; Nakano, Kimisato; Morioka, Shigefumi; Okada, Yukikatsu; Shiratori, Kenichi; Kihara, Yasuki; Nasu, Michihiro; Nobuyoshi, Masakiyo; Okabayashi, Hitoshi; Yasumoto, Hitoshi; Nakano, Jyota; Murakami, Tomoyuki; Ishida, Katsuya; Ogawa, Hisao; Kawasuji, Michio; Sugiyama, Seigo; Hagiwara, Shoichiro; Mitsudo, Kazuaki; Komiya, Tatsuhiko; Kadota, Kazushige; Komeda, Masashi; Tatami, Ryozo; Ushijima, Teruaki; Yoshida, Akira; Nakajima, Hiroyuki; Miki, Shinji; Hattori, Ryuichi; Nishiwaki, Noboru; Shirotani, Manabu; Kato, Hiroshi; Eizawa, Hiroshi; Tanaka, Masaru; Minami, Kazuaki; Horie, Minoru; Asai, Tohru; Takashima, Hiroyuki; Higashita, Ryuji; Takahashi, Mamoru; Tahata, Takafumi; Matoba, Yoshiki; Doyama, Kiyoshi; Araki, Makoto; Takizawa, Akinori; Shimamoto, Mitsuomi; Yamazaki, Fumio; Doi, Osamu; Kambara, Hirofumi; Matsuda, Katsuhiko; Kaburagi, Satoshi; Nara, Masafumi; Kawanami, Masaki; Konishi, Takashi; Nishimura, Kazunobu; Ootani, Seiji; Sugita, Takaaki.

In: Circulation Journal, Vol. 72, No. 12, 03.12.2008, p. 1937-1945.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Better survival with statin administration after revascularization therapy in Japanese patients with coronary artery disease - Perspectives from the CREDO-Kyoto Registry

AU - Furukawa, Yutaka

AU - Taniguchi, Ryoji

AU - Ehara, Natsuhiko

AU - Ozasa, Neiko

AU - Haruna, Yoshisumi

AU - Saito, Naritatsu

AU - Doi, Takahiro

AU - Hoshino, Kozo

AU - Shizuta, Satoshi

AU - Morimoto, Takeshi

AU - Imai, Yukiko

AU - Teramukai, Satoshi

AU - Fukushima, Masanori

AU - Kita, Toru

AU - Kimura, Takeshi

AU - Lee, Jong Dae

AU - Tanaka, Kuniyoshi

AU - Okazaki, Katsuo

AU - Takahashi, Masaaki

AU - Oda, Teiji

AU - Matsui, Shigeo

AU - Ohashi, Naohiro

AU - Matsuyama, Eiichi

AU - Kadoya, Makoto

AU - Takatsu, Yoshiki

AU - Nomoto, Shinichi

AU - Kataoka, Kazuaki

AU - Kotoura, Hajime

AU - Aota, Masaki

AU - Miura, Akira

AU - Suwa, Satoru

AU - Tei, Chuwa

AU - Sakata, Ryuzo

AU - Hamasaki, Shuichi

AU - Yamamoto, Hiroyuki

AU - Aoyama, Takeshi

AU - Sakurai, Takahiro

AU - Matsuda, Mitsuo

AU - Onoe, Masahiko

AU - Takeuchi, Yuzo

AU - Nohara, Ryuji

AU - Nakano, Kimisato

AU - Morioka, Shigefumi

AU - Okada, Yukikatsu

AU - Shiratori, Kenichi

AU - Kihara, Yasuki

AU - Nasu, Michihiro

AU - Nobuyoshi, Masakiyo

AU - Okabayashi, Hitoshi

AU - Yasumoto, Hitoshi

AU - Nakano, Jyota

AU - Murakami, Tomoyuki

AU - Ishida, Katsuya

AU - Ogawa, Hisao

AU - Kawasuji, Michio

AU - Sugiyama, Seigo

AU - Hagiwara, Shoichiro

AU - Mitsudo, Kazuaki

AU - Komiya, Tatsuhiko

AU - Kadota, Kazushige

AU - Komeda, Masashi

AU - Tatami, Ryozo

AU - Ushijima, Teruaki

AU - Yoshida, Akira

AU - Nakajima, Hiroyuki

AU - Miki, Shinji

AU - Hattori, Ryuichi

AU - Nishiwaki, Noboru

AU - Shirotani, Manabu

AU - Kato, Hiroshi

AU - Eizawa, Hiroshi

AU - Tanaka, Masaru

AU - Minami, Kazuaki

AU - Horie, Minoru

AU - Asai, Tohru

AU - Takashima, Hiroyuki

AU - Higashita, Ryuji

AU - Takahashi, Mamoru

AU - Tahata, Takafumi

AU - Matoba, Yoshiki

AU - Doyama, Kiyoshi

AU - Araki, Makoto

AU - Takizawa, Akinori

AU - Shimamoto, Mitsuomi

AU - Yamazaki, Fumio

AU - Doi, Osamu

AU - Kambara, Hirofumi

AU - Matsuda, Katsuhiko

AU - Kaburagi, Satoshi

AU - Nara, Masafumi

AU - Kawanami, Masaki

AU - Konishi, Takashi

AU - Nishimura, Kazunobu

AU - Ootani, Seiji

AU - Sugita, Takaaki

PY - 2008/12/3

Y1 - 2008/12/3

N2 - Background: The importance of statins in cardiovascular prevention has been demonstrated in various patient subsets. This study aimed to evaluate the effects of statins on long-term outcomes of Japanese patients undergoing their first coronary revascularization. Methods and Results: A total of 9,225 patients undergoing their first coronary revascularizations during 2000-2002 were divided into 2 groups according to the use of statins at discharge; patients with acute myocardial infarction were not included. Statins was administered to only 28.5% (n=2,630) of the patients. The median follow-up period was 3.5 years. Patients on statin therapy showed lower all-cause (5.2% vs 10.0%; p<0.0001) and cardiovascular (3.2% vs 6.2%; p<0.0001) mortality than those without statins (n=6,595) by Kaplan-Meier analysis and log-rank test. After adjustment by multivariate analysis according to 29 variables, statin therapy remained as an independent predictor of reduced all-cause (relative risk ratio (RR) 0.71, 95% confidence interval (CI) 0.59-0.86, p=0.0005) and cardiovascular (RR 0.72, 95% CI 0.56-0.91, p=0.0067) mortality. The validity of RR of statin therapy in multivariate analysis was further confirmed by risk adjustment using propensity scores (all-cause mortality: propensity-adjusted RR 0.70, 95% CI 0.58-0.85, p=0.0003; cardiovascular mortality: propensity-adjusted RR 0.70, 95% CI 0.54-0.89, p=0.0038). Conclusions: Statin therapy started at hospital discharge was associated with increased chance of survival in Japanese patients undergoing their first coronary revascularization.

AB - Background: The importance of statins in cardiovascular prevention has been demonstrated in various patient subsets. This study aimed to evaluate the effects of statins on long-term outcomes of Japanese patients undergoing their first coronary revascularization. Methods and Results: A total of 9,225 patients undergoing their first coronary revascularizations during 2000-2002 were divided into 2 groups according to the use of statins at discharge; patients with acute myocardial infarction were not included. Statins was administered to only 28.5% (n=2,630) of the patients. The median follow-up period was 3.5 years. Patients on statin therapy showed lower all-cause (5.2% vs 10.0%; p<0.0001) and cardiovascular (3.2% vs 6.2%; p<0.0001) mortality than those without statins (n=6,595) by Kaplan-Meier analysis and log-rank test. After adjustment by multivariate analysis according to 29 variables, statin therapy remained as an independent predictor of reduced all-cause (relative risk ratio (RR) 0.71, 95% confidence interval (CI) 0.59-0.86, p=0.0005) and cardiovascular (RR 0.72, 95% CI 0.56-0.91, p=0.0067) mortality. The validity of RR of statin therapy in multivariate analysis was further confirmed by risk adjustment using propensity scores (all-cause mortality: propensity-adjusted RR 0.70, 95% CI 0.58-0.85, p=0.0003; cardiovascular mortality: propensity-adjusted RR 0.70, 95% CI 0.54-0.89, p=0.0038). Conclusions: Statin therapy started at hospital discharge was associated with increased chance of survival in Japanese patients undergoing their first coronary revascularization.

KW - Coronary artery disease

KW - Mortality

KW - Revascularization

KW - Statins

UR - http://www.scopus.com/inward/record.url?scp=56849126602&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56849126602&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-08-0293

DO - 10.1253/circj.CJ-08-0293

M3 - Article

C2 - 18948669

AN - SCOPUS:56849126602

VL - 72

SP - 1937

EP - 1945

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 12

ER -