Abstract
β-catenin is widely regarded as the primary transducer of canonical WNT signals to the nucleus. In most vertebrates, there are eight additional catenins that are structurally related to β-catenin, and three α-catenin genes encoding actin-binding proteins that are structurally related to vinculin. Although these catenins were initially identified in association with cadherins at cell-cell junctions, more recent evidence suggests that the majority of catenins also localize to the nucleus and regulate gene expression. Moreover, the number of catenins reported to be responsive to canonical WNT signals is increasing. Here, we posit that multiple catenins form a functional network in the nucleus, possibly engaging in conserved protein-protein interactions that are currently better characterized in the context of actin-based cell junctions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 55-64 |
| Number of pages | 10 |
| Journal | Nature Reviews Molecular Cell Biology |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2016 |
Funding
The authors thank their colleagues in the field, and the reviewers for their helpful comments, and apologize to those whose work was not cited owing to space considerations. P.D.M. was supported by U.S. National Institutes of Health (NIH) grant GM107079 and C.J.G. by GM076561.
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology