Beyond histology: Translating tumor genotypes into clinically effective targeted therapies

Catherine B. Meador; Christine M. Micheel; Mia A. Levy; Christine M. Lovly; Leora Horn; Jeremy L. Warner; Douglas B. Johnson; Zhongming Zhao; Ingrid A. Anderson; Jeffrey A. Sosman; Cindy L. Vnencak-Jones; Kimberly B. Dahlman; William Pao

doi:10.1158/1078-0432.CCR-13-1591

Beyond histology: Translating tumor genotypes into clinically effective targeted therapies

Catherine B. Meador, Christine M. Micheel, Mia A. Levy, Christine M. Lovly, Leora Horn, Jeremy L. Warner, Douglas B. Johnson, Zhongming Zhao, Ingrid A. Anderson, Jeffrey A. Sosman, Cindy L. Vnencak-Jones, Kimberly B. Dahlman, William Pao^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Increased understanding of intertumoral heterogeneity at the genomic level has led to significant advancements in the treatment of solid tumors. Functional genomic alterations conferring sensitivity to targeted therapies can take many forms, and appropriate methods and tools are needed to detect these alterations. This review provides an update on genetic variability among solid tumors of similar histologic classification, using non-small cell lung cancer and melanoma as examples. We also discuss relevant technological platforms for discovery and diagnosis of clinically actionable variants and highlight the implications of specific genomic alterations for response to targeted therapy.

Original language	English (US)
Pages (from-to)	2264-2275
Number of pages	12
Journal	Clinical Cancer Research
Volume	20
Issue number	9
DOIs	https://doi.org/10.1158/1078-0432.CCR-13-1591
State	Published - May 1 2014

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1078-0432.CCR-13-1591

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Meador, C. B., Micheel, C. M., Levy, M. A., Lovly, C. M., Horn, L., Warner, J. L., Johnson, D. B., Zhao, Z., Anderson, I. A., Sosman, J. A., Vnencak-Jones, C. L., Dahlman, K. B., & Pao, W. (2014). Beyond histology: Translating tumor genotypes into clinically effective targeted therapies. Clinical Cancer Research, 20(9), 2264-2275. https://doi.org/10.1158/1078-0432.CCR-13-1591

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AU - Levy, Mia A.

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AU - Horn, Leora

AU - Warner, Jeremy L.

AU - Johnson, Douglas B.

AU - Zhao, Zhongming

AU - Anderson, Ingrid A.

AU - Sosman, Jeffrey A.

AU - Vnencak-Jones, Cindy L.

AU - Dahlman, Kimberly B.

AU - Pao, William

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Beyond histology: Translating tumor genotypes into clinically effective targeted therapies

Abstract

ASJC Scopus subject areas

UN SDGs

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