Beyond serotonin

H. Y. Meltzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Available therapies for treating depression, even the specific serotonin reuptake blockers, may not act via a serotonergic mechanism. Regardless of the mechanism of action, limitations in efficacy, onset of action, and side effects of all available antidepressant drugs indicate the need for further efforts to develop superior treatments of depression. A number of novel approaches are currently being investigated, including β-adrenergic agonists, α-adrenergic antagonists, tetrahydrobiopterin, GABAergic drugs and non-pharmacologic therapies such as light therapy. These treatments may act independently of serotonin, yet there are intriguing suggestions that even their action is linked to serotonin.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalJournal of Clinical Psychiatry
Issue number5 SUPPL.
StatePublished - 1991

ASJC Scopus subject areas

  • Psychiatry and Mental health

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