Beyond the Capture of Circulating Tumor Cells: Next-Generation Devices and Materials

Brenda J. Green, Tina Saberi Safaei, Adam Mepham, Mahmoud Labib, Reza M. Mohamadi, Shana O. Kelley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

131 Scopus citations


Over the last decade, significant progress has been made towards the development of approaches that enable the capture of rare circulating tumor cells (CTCs) from the blood of cancer patients, a critical capability for noninvasive tumor profiling. These advances have leveraged new insights in materials chemistry and microfluidics and allowed the capture and enumeration of CTCs with unprecedented sensitivity. However, it has become increasingly clear that simply capturing and counting tumor cells launched into the bloodstream may not provide the information needed to advance our understanding of the biology of these rare cells, or to allow us to better exploit them in medicine. A variety of advances have now emerged demonstrating that more information can be extracted from CTCs with next-generation devices and materials featuring tailored physical and chemical properties. In this Minireview, the last ten years of work in this area will be discussed, with an emphasis on the groundbreaking work of the last five years, during which the focus has moved beyond the simple capture of CTCs and gravitated towards approaches that enable in-depth analysis.

Original languageEnglish (US)
Pages (from-to)1252-1265
Number of pages14
JournalAngewandte Chemie - International Edition
Issue number4
StatePublished - Jan 22 2016
Externally publishedYes


  • cancer
  • cell analysis
  • circulating tumor cells
  • microfluidics
  • nanomaterials

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis


Dive into the research topics of 'Beyond the Capture of Circulating Tumor Cells: Next-Generation Devices and Materials'. Together they form a unique fingerprint.

Cite this