Beyond thrombosis: The impact of tissue factor signaling in cancer

Dusten Unruh*, Craig Horbinski

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend well beyond hemostasis. When TF binds to Factor VII, the resulting TF:FVIIa complex can proteolytically cleave transmembrane G protein-coupled protease-activated receptors (PARs). In addition to activating PARs, TF:FVIIa complex can also activate receptor tyrosine kinases (RTKs) and integrins. These signaling pathways are utilized by tumors to increase cell proliferation, angiogenesis, metastasis, and cancer stem-like cell maintenance. Herein, we review in detail the regulation of TF expression, mechanisms of TF signaling, their pathological consequences, and how it is being targeted in experimental cancer therapeutics.

Original languageEnglish (US)
Article number93
JournalJournal of Hematology and Oncology
Volume13
Issue number1
DOIs
StatePublished - Jul 14 2020

Keywords

  • Angiogenesis
  • Integrins
  • Metastasis
  • Protease-activated receptors
  • Receptor tyrosine kinases
  • Tissue factor

ASJC Scopus subject areas

  • Hematology
  • Molecular Biology
  • Oncology
  • Cancer Research

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