Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila

Caroline A. Doherty; Farners Amargant; Stanislav Y. Shvartsman; Francesca E. Duncan; Elizabeth R. Gavis

doi:10.1016/j.tcb.2021.11.005

Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila

Caroline A. Doherty, Farners Amargant, Stanislav Y. Shvartsman^*, Francesca E. Duncan, Elizabeth R. Gavis

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

In most animals, the oocyte is the largest cell by volume. The oocyte undergoes a period of large-scale growth during its development, prior to fertilization. At first glance, tissues that support the development of the oocyte in different organisms have diverse cellular characteristics that would seem to prohibit functional comparisons. However, these tissues often act with a common goal of establishing dynamic forms of two-way communication with the oocyte. We propose that this bidirectional communication between oocytes and support cells is a universal phenomenon that can be directly compared across species. Specifically, we highlight fruit fly and mouse oogenesis to demonstrate that similarities and differences in these systems should be used to inform and design future experiments in both models.

Original language	English (US)
Pages (from-to)	311-323
Number of pages	13
Journal	Trends in Cell Biology
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.tcb.2021.11.005
State	Published - Apr 2022

Funding

We thank Lucy Reading-Ikkanda (Flatiron Institute) for figure artwork, Trudi Schüpbach for helpful discussions, and the reviewers for insightful feedback. This work was supported by National Institutes of Health grants R35 GM126967 to E.R.G.; R01 HD093726 , R01 HD105752 , and R21 HD098498 to F.E.D.; and R01 GM134204 to S.Y.S. C.A.D. was supported by National Institutes of Health training grant T32 GM007388 and F.A. was supported by the Global Consortium for Reproductive Longevity and Equality ( GCRLE-1720 ) postdoctoral grant. We thank Lucy Reading-Ikkanda (Flatiron Institute) for figure artwork, Trudi Schüpbach for helpful discussions, and the reviewers for insightful feedback. This work was supported by National Institutes of Health grants R35 GM126967 to E.R.G.; R01 HD093726, R01 HD105752, and R21 HD098498 to F.E.D.; and R01 GM134204 to S.Y.S. C.A.D. was supported by National Institutes of Health training grant T32 GM007388 and F.A. was supported by the Global Consortium for Reproductive Longevity and Equality (GCRLE-1720) postdoctoral grant. The authors declare no competing interests.

Keywords

bidirectional communication
folliculogenesis
oogenesis
reproductive aging

ASJC Scopus subject areas

Cell Biology

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10.1016/j.tcb.2021.11.005

Cite this

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title = "Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila",

abstract = "In most animals, the oocyte is the largest cell by volume. The oocyte undergoes a period of large-scale growth during its development, prior to fertilization. At first glance, tissues that support the development of the oocyte in different organisms have diverse cellular characteristics that would seem to prohibit functional comparisons. However, these tissues often act with a common goal of establishing dynamic forms of two-way communication with the oocyte. We propose that this bidirectional communication between oocytes and support cells is a universal phenomenon that can be directly compared across species. Specifically, we highlight fruit fly and mouse oogenesis to demonstrate that similarities and differences in these systems should be used to inform and design future experiments in both models.",

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AU - Gavis, Elizabeth R.

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AB - In most animals, the oocyte is the largest cell by volume. The oocyte undergoes a period of large-scale growth during its development, prior to fertilization. At first glance, tissues that support the development of the oocyte in different organisms have diverse cellular characteristics that would seem to prohibit functional comparisons. However, these tissues often act with a common goal of establishing dynamic forms of two-way communication with the oocyte. We propose that this bidirectional communication between oocytes and support cells is a universal phenomenon that can be directly compared across species. Specifically, we highlight fruit fly and mouse oogenesis to demonstrate that similarities and differences in these systems should be used to inform and design future experiments in both models.

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Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila

Abstract

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Keywords

ASJC Scopus subject areas

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