Bidirectional contingent cross tolerance between the anticonvulsant effects of pentobarbital and ethanol

Kwon Kim C. Kwon Kim, John P J Pinel, Neal R. Roese

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In Experiment 1, two groups of kindled rats received a pentobarbital injection (15 mg/kg, IP) and a convulsive amygdala stimulation once every 48 h. In one group, pentobarbital was injected 1 h before each stimulation; in the other, it was injected 1 h after each stimulation. Only the rats that received pentobarbital before each stimulation became tolerant to pentobarbital's anticonvulsant effect. Cross tolerance to the anti-convulsant effect of ethanol (1.5 g/kg, IP) was also found to be greater in the pentobarbital-before-stimulation rats. Experiment 2 was designed to assess the transfer of tolerance in the opposite direction, that is, from ethanol to pentobarbital, and the results mirrored those of Experiment 1: convulsive stimulation during the periods of ethanol exposure facilitated the development of tolerance to the anticonvulsant effect of ethanol and its transfer to pentobarbital. These results support the theory that functional drug tolerance and cross tolerance are adaptations to the effects of drugs on concurrent patterns of neural activity rather than to drug exposure per se.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume41
Issue number1
DOIs
StatePublished - Jan 1992

Keywords

  • Alcohol
  • Amygdala
  • Anticonvulsant
  • Behavioral tolerance
  • Contingent tolerance
  • Convulsion
  • Cross tolerance
  • Ethanol
  • Kindling
  • Pentobarbital
  • Rat
  • Seizure
  • Tolerance

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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