Bidirectional intracellular transport: Utility and mechanism

Amber L. Jolly, Vladimir I. Gelfand*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Bidirectional transport of intracellular cargo along microtubule tracks is the subject of intense debate in the motility field. In the present review, we provide an overview of the models describing the possible mechanisms driving intracellular saltatory transport, taking into account current experimental results that may at first seem contradictory. We examine the phenomenon of saltatorymotion, in an attempt to interpret the mechanistic debate in terms of the utility of saltatory motion.

Original languageEnglish (US)
Pages (from-to)1126-1130
Number of pages5
JournalBiochemical Society transactions
Volume39
Issue number5
DOIs
StatePublished - Oct 2011

Keywords

  • Bidirectional intracellular transport
  • Cargo transport
  • Dynein
  • Kinesin
  • Microtubule cytoskeleton
  • Myosin

ASJC Scopus subject areas

  • Biochemistry

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