TY - JOUR
T1 - Bilateral optic nerve infiltration in central nervous system leukemia
AU - Schocket, Lisa S.
AU - Massaro-Giordano, Mina
AU - Volpe, Nicholas J.
AU - Galetta, Steven L.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - PURPOSE: To report the case of a 58-year-old man with sequential bilateral retrolaminar leukemic infiltration of the optic nerves who presented with normal-appearing optic nerves and no optic nerve enhancement. DESIGN: Interventional case report. METHODS: A 58-year-old man with chronic myelogenous leukemia (CML) developed progressive vision loss to no light perception in both eyes over four days. RESULTS: The patient received 14 doses of external beam irradiation and 10 cycles of intrathecal cytarabine. Despite treatment, he developed optic nerve pallor, and visual acuity remained no light perception in both eyes. CONCLUSIONS: In a patient with leukemia, leukemic optic nerve infiltration may occur even with normal-appearing optic nerves and a normal magnetic resonance image. It is important to maintain a high clinical suspicion for optic nerve infiltration so that prompt local irradiation may be initiated.
AB - PURPOSE: To report the case of a 58-year-old man with sequential bilateral retrolaminar leukemic infiltration of the optic nerves who presented with normal-appearing optic nerves and no optic nerve enhancement. DESIGN: Interventional case report. METHODS: A 58-year-old man with chronic myelogenous leukemia (CML) developed progressive vision loss to no light perception in both eyes over four days. RESULTS: The patient received 14 doses of external beam irradiation and 10 cycles of intrathecal cytarabine. Despite treatment, he developed optic nerve pallor, and visual acuity remained no light perception in both eyes. CONCLUSIONS: In a patient with leukemia, leukemic optic nerve infiltration may occur even with normal-appearing optic nerves and a normal magnetic resonance image. It is important to maintain a high clinical suspicion for optic nerve infiltration so that prompt local irradiation may be initiated.
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U2 - 10.1016/S0002-9394(02)01847-0
DO - 10.1016/S0002-9394(02)01847-0
M3 - Article
C2 - 12504706
AN - SCOPUS:0037216516
SN - 0002-9394
VL - 135
SP - 94
EP - 96
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 1
ER -