Bilirubin accumulates within, and induces loose coupling in, rat liver mitochondria. This state, characterized by a normal protonmotive force, but increased oxygen consumption and inner membrane conductance, could impair cellular energy metabolism. Loose coupling is observed at bilirubin concentrations (12-24 μm) attained in tissues of kernicteric animals.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Oct 1985|
ASJC Scopus subject areas