Bilirubin increases mitochondrial inner membrane conductance

David A. Stumpf; Luis A. Eguren; Janice K. Parks

doi:10.1016/0006-2944(85)90115-2

Bilirubin increases mitochondrial inner membrane conductance

David A. Stumpf^*, Luis A. Eguren, Janice K. Parks

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Bilirubin accumulates within, and induces loose coupling in, rat liver mitochondria. This state, characterized by a normal protonmotive force, but increased oxygen consumption and inner membrane conductance, could impair cellular energy metabolism. Loose coupling is observed at bilirubin concentrations (12-24 μm) attained in tissues of kernicteric animals.

Original language	English (US)
Pages (from-to)	226-229
Number of pages	4
Journal	Biochemical medicine
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/0006-2944(85)90115-2
State	Published - Oct 1985

ASJC Scopus subject areas

Biochemistry

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10.1016/0006-2944(85)90115-2

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@article{026cc55d12bd4ead9d49528d36e476b3,

title = "Bilirubin increases mitochondrial inner membrane conductance",

abstract = "Bilirubin accumulates within, and induces loose coupling in, rat liver mitochondria. This state, characterized by a normal protonmotive force, but increased oxygen consumption and inner membrane conductance, could impair cellular energy metabolism. Loose coupling is observed at bilirubin concentrations (12-24 μm) attained in tissues of kernicteric animals.",

author = "Stumpf, {David A.} and Eguren, {Luis A.} and Parks, {Janice K.}",

note = "Funding Information: This work was supported by a clinical research grant from the Muscular Dystrophy Association; a grant from the National Foundation-March of Dimes; and NIH Program Project Grant HDO8315. Center Grant HDO4024, and National Research Service Award Grant HD 07096-01. all from NICHD.",

year = "1985",

month = oct,

doi = "10.1016/0006-2944(85)90115-2",

language = "English (US)",

volume = "34",

pages = "226--229",

journal = "Biochemical medicine",

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number = "2",

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TY - JOUR

T1 - Bilirubin increases mitochondrial inner membrane conductance

AU - Stumpf, David A.

AU - Eguren, Luis A.

AU - Parks, Janice K.

N1 - Funding Information: This work was supported by a clinical research grant from the Muscular Dystrophy Association; a grant from the National Foundation-March of Dimes; and NIH Program Project Grant HDO8315. Center Grant HDO4024, and National Research Service Award Grant HD 07096-01. all from NICHD.

PY - 1985/10

Y1 - 1985/10

N2 - Bilirubin accumulates within, and induces loose coupling in, rat liver mitochondria. This state, characterized by a normal protonmotive force, but increased oxygen consumption and inner membrane conductance, could impair cellular energy metabolism. Loose coupling is observed at bilirubin concentrations (12-24 μm) attained in tissues of kernicteric animals.

AB - Bilirubin accumulates within, and induces loose coupling in, rat liver mitochondria. This state, characterized by a normal protonmotive force, but increased oxygen consumption and inner membrane conductance, could impair cellular energy metabolism. Loose coupling is observed at bilirubin concentrations (12-24 μm) attained in tissues of kernicteric animals.

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U2 - 10.1016/0006-2944(85)90115-2

DO - 10.1016/0006-2944(85)90115-2

M3 - Article

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VL - 34

SP - 226

EP - 229

JO - Biochemical medicine

JF - Biochemical medicine

IS - 2

ER -

Bilirubin increases mitochondrial inner membrane conductance

Abstract

ASJC Scopus subject areas

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