Bilirubin increases mitochondrial inner membrane conductance

David A. Stumpf*, Luis A. Eguren, Janice K. Parks

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Bilirubin accumulates within, and induces loose coupling in, rat liver mitochondria. This state, characterized by a normal protonmotive force, but increased oxygen consumption and inner membrane conductance, could impair cellular energy metabolism. Loose coupling is observed at bilirubin concentrations (12-24 μm) attained in tissues of kernicteric animals.

Original languageEnglish (US)
Pages (from-to)226-229
Number of pages4
JournalBiochemical medicine
Issue number2
StatePublished - Oct 1985

ASJC Scopus subject areas

  • Biochemistry


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