TY - JOUR
T1 - Binding of labeled N methyl N nitrosourea to macromolecules of squamous and glandular stomach of rats
AU - Musunuri, Sambasiva Rao
AU - Reddy, Janardan K
PY - 1976/12/1
Y1 - 1976/12/1
N2 - The binding of labeled N methyl N nitrosourea (3H MNU) to macromolecules of squamous and glandular stomach of rats, that were either pretreated with N methyl N nitrosourea (MNU) for different periods or without pretreatment, is studied. The results showed no significant difference in the binding of labeled carcinogen to DNA and RNA of the two portions of stomach. However, a significant increase was noted in the incorporated 3H MNU in proteins of glandular stomach with or without pretreatment with MNU. From these studies it is implied that carcinogenic effect of MNU may be through interaction with some other molecule(s) rather than with nucleic acids and/or proteins.
AB - The binding of labeled N methyl N nitrosourea (3H MNU) to macromolecules of squamous and glandular stomach of rats, that were either pretreated with N methyl N nitrosourea (MNU) for different periods or without pretreatment, is studied. The results showed no significant difference in the binding of labeled carcinogen to DNA and RNA of the two portions of stomach. However, a significant increase was noted in the incorporated 3H MNU in proteins of glandular stomach with or without pretreatment with MNU. From these studies it is implied that carcinogenic effect of MNU may be through interaction with some other molecule(s) rather than with nucleic acids and/or proteins.
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M3 - Article
C2 - 981794
AN - SCOPUS:0017163265
VL - 15
SP - 373
EP - 376
JO - Research Communications in Chemical Pathology and Pharmacology
JF - Research Communications in Chemical Pathology and Pharmacology
SN - 0034-5164
IS - 2
ER -