Binding of octa-plus porphyrazines to DNA

Máirín E. Anderson, Anthony G.M. Barrett, Brian M. Hoffman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


We present a preliminary report of the interaction of octacationic N- methyl-pyridyl metalloporphyrazines, M = Cu(II) (Cupz+8) and Zn(II) (Znpz+8), with calf thymus DNA. These were monitored by electronic absorption spectroscopy, and in the case of Znpz+8, also by emission spectroscopy. These studies show that both the Cupz+8 and Znpz+8 interact strongly with DNA, and at sufficient concentrations induce a highly colored precipitate. The spectrum of Cupz+8 red-shifts as DNA is added, which is interpreted as indicative of π stacking of the charged macrocycle as it binds electrostatically to the outside of the DNA duplex. The spectrum of Znpz+8 does not shift, indicative of simple electrostatic surface binding. The absence of stacking may be related to the presence of an axial metal-ion ligand for Znpz+8, presumably 1120, while the metal ion of Cupz+8 is four-coordinate. (C) 2000 Published by Elsevier Science S.A.

Original languageEnglish (US)
Pages (from-to)257-260
Number of pages4
JournalJournal of Inorganic Biochemistry
Issue number3-4
StatePublished - Jul 1 2000


  • Porphyrin
  • Stacking

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry


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