Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals

Raquel B. De Boni*, Lu Zheng, Susan L. Rosenkranz, Xin Sun, Jeffrey Lavenberg, Sandra W. Cardoso, Beatriz Grinsztejn, Alberto La Rosa, Samuel Pierre, Patrice Severe, Susan E. Cohn, Ann C. Collier, Robert Gross

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Understanding patterns of antiretroviral adherence and its predictors is important for designing tailored interventions. Alcohol use is associated with non-adherence. This study aimed to evaluate: (1) if there was a difference in weekday compared with weekend adherence in HIV-infected individuals from low and middle income countries (LMIC), and (2) whether binge drinking was associated with this difference. Methods: Data from a randomized trial conducted at 9 sites in 8 LMIC were analyzed. Microelectronic monitors were used to measure adherence. Differences between weekday and weekend adherence in each quarter (successive 12-week periods) were compared using Wilcoxon signed rank tests and predictors of adherence, including baseline binge drinking, were evaluated using Generalized Estimating Equations. Results: Data from 255 participants were analyzed: 49.8% were male, median age was 37 years and 28.6% enrolled in Haiti. At study entry, only 2.7% reported illicit substance use, but 22.3% reported binge drinking at least once in the 30 days prior to enrollment. Adherence was higher on weekdays than weekends (median percent doses taken: 96.0% vs 94.4%; 93.7% vs 91.7%; 92.6% vs 89.7% and 93.7% vs 89.7% in quarters 1-4 respectively, all p<. 0.001). Binge drinking at baseline and time on study were both associated with greater differences between weekday and weekend adherence. Conclusions: Adherence was worse on weekends compared to weekdays: difference was small at treatment initiation, increased over time and was associated with binge drinking. Screening and new interventions to address binge drinking, a potentially modifiable behavior, may improve adherence in HIV-infected individuals in LMIC.

Original languageEnglish (US)
Pages (from-to)174-180
Number of pages7
JournalDrug and Alcohol Dependence
Volume159
DOIs
StatePublished - Feb 1 2016

Keywords

  • Adherence
  • Alcohol
  • Binge drinking
  • HIV/AIDS
  • Low and middle income countries
  • Microelectronic monitors

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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