Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals

Raquel B. De Boni*, Lu Zheng, Susan L. Rosenkranz, Xin Sun, Jeffrey Lavenberg, Sandra W. Cardoso, Beatriz Grinsztejn, Alberto La Rosa, Samuel Pierre, Patrice Severe, Susan E. Cohn, Ann C. Collier, Robert Gross

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background: Understanding patterns of antiretroviral adherence and its predictors is important for designing tailored interventions. Alcohol use is associated with non-adherence. This study aimed to evaluate: (1) if there was a difference in weekday compared with weekend adherence in HIV-infected individuals from low and middle income countries (LMIC), and (2) whether binge drinking was associated with this difference. Methods: Data from a randomized trial conducted at 9 sites in 8 LMIC were analyzed. Microelectronic monitors were used to measure adherence. Differences between weekday and weekend adherence in each quarter (successive 12-week periods) were compared using Wilcoxon signed rank tests and predictors of adherence, including baseline binge drinking, were evaluated using Generalized Estimating Equations. Results: Data from 255 participants were analyzed: 49.8% were male, median age was 37 years and 28.6% enrolled in Haiti. At study entry, only 2.7% reported illicit substance use, but 22.3% reported binge drinking at least once in the 30 days prior to enrollment. Adherence was higher on weekdays than weekends (median percent doses taken: 96.0% vs 94.4%; 93.7% vs 91.7%; 92.6% vs 89.7% and 93.7% vs 89.7% in quarters 1-4 respectively, all p<. 0.001). Binge drinking at baseline and time on study were both associated with greater differences between weekday and weekend adherence. Conclusions: Adherence was worse on weekends compared to weekdays: difference was small at treatment initiation, increased over time and was associated with binge drinking. Screening and new interventions to address binge drinking, a potentially modifiable behavior, may improve adherence in HIV-infected individuals in LMIC.

Original languageEnglish (US)
Pages (from-to)174-180
Number of pages7
JournalDrug and Alcohol Dependence
Volume159
DOIs
StatePublished - Feb 1 2016

Funding

The authors wish to thank to the AIDS Clinical Trials Group (ACTG) and SDMC. We would like to acknowledge the following individual sites’ grant support, study team members, and site personnel: Les Centres GHESKIO CRS (Site 30022) ACTG CTU Grant; Joint Clinical Research Centre CRS (Site 12401) ACTG CTU Grant U01- A1069501; Parirenyatwa CRS (Site 30313) ACTG CTU Grant UM 1AI069436; Wits HIV CRS (Site 11101) ACTG CTU Grant AI069463; Barranco CRS (Site 11301) ACTG CTU Grant 2UM1AI069438-08; San Miguel CRS (Site 11302) ACTG CTU Grant AI069438; Kalingalinga Clinic CRS (Site 12801) ACTG CTU Grant 7UMIA1069455; Gaborone Prevention/Treatment Trials CRS (Site 12701) ACTG CTU Grant 2UMIAI069456-08; CFDA Grant 93.865; Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS (Site 12101) ACTG CTU Grant AI069476 and Northwestern ACTG Grant 1U01AI069471. We also would like to thank to AbbVie Inc. and Gilead Pharmaceuticals, which provided the medications for the trial. The authors wish to thank to the AIDS Clinical Trials Group (ACTG) and SDMC. We would like to acknowledge the follow- ing individual sites’ grant support, study team members, and site personnel: Les Centres GHESKIO CRS (Site 30022) ACTG CTU Grant; Joint Clinical Research Centre CRS (Site 12401) ACTG CTU Grant U01- A1069501; Parirenyatwa CRS (Site 30313) ACTG CTU Grant UM 1AI069436; Wits HIV CRS (Site 11101) ACTG CTU Grant AI069463; Barranco CRS (Site 11301) ACTG CTU Grant 2UM1AI069438-08; San Miguel CRS (Site 11302) ACTG CTU Grant AI069438; Kalingalinga Clinic CRS (Site 12801) ACTG CTU Grant 7UMIA1069455; Gaborone Prevention/Treatment Trials CRS (Site 12701) ACTG CTU Grant 2UMIAI069456-08; CFDA Grant 93. 865; Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS (Site 12101) ACTG CTU Grant AI069476 and Northwestern ACTG Grant 1U01AI069471. We also would like to thank to AbbVie Inc. and Gilead Pharmaceuticals, which provided the medications for the trial.

Keywords

  • Adherence
  • Alcohol
  • Binge drinking
  • HIV/AIDS
  • Low and middle income countries
  • Microelectronic monitors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Toxicology
  • Pharmacology

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