Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals

Raquel B. De Boni; Lu Zheng; Susan L. Rosenkranz; Xin Sun; Jeffrey Lavenberg; Sandra W. Cardoso; Beatriz Grinsztejn; Alberto La Rosa; Samuel Pierre; Patrice Severe; Susan E. Cohn; Ann C. Collier; Robert Gross

doi:10.1016/j.drugalcdep.2015.12.013

Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals

Raquel B. De Boni^*, Lu Zheng, Susan L. Rosenkranz, Xin Sun, Jeffrey Lavenberg, Sandra W. Cardoso, Beatriz Grinsztejn, Alberto La Rosa, Samuel Pierre, Patrice Severe, Susan E. Cohn, Ann C. Collier, Robert Gross

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: Understanding patterns of antiretroviral adherence and its predictors is important for designing tailored interventions. Alcohol use is associated with non-adherence. This study aimed to evaluate: (1) if there was a difference in weekday compared with weekend adherence in HIV-infected individuals from low and middle income countries (LMIC), and (2) whether binge drinking was associated with this difference. Methods: Data from a randomized trial conducted at 9 sites in 8 LMIC were analyzed. Microelectronic monitors were used to measure adherence. Differences between weekday and weekend adherence in each quarter (successive 12-week periods) were compared using Wilcoxon signed rank tests and predictors of adherence, including baseline binge drinking, were evaluated using Generalized Estimating Equations. Results: Data from 255 participants were analyzed: 49.8% were male, median age was 37 years and 28.6% enrolled in Haiti. At study entry, only 2.7% reported illicit substance use, but 22.3% reported binge drinking at least once in the 30 days prior to enrollment. Adherence was higher on weekdays than weekends (median percent doses taken: 96.0% vs 94.4%; 93.7% vs 91.7%; 92.6% vs 89.7% and 93.7% vs 89.7% in quarters 1-4 respectively, all p<. 0.001). Binge drinking at baseline and time on study were both associated with greater differences between weekday and weekend adherence. Conclusions: Adherence was worse on weekends compared to weekdays: difference was small at treatment initiation, increased over time and was associated with binge drinking. Screening and new interventions to address binge drinking, a potentially modifiable behavior, may improve adherence in HIV-infected individuals in LMIC.

Original language	English (US)
Pages (from-to)	174-180
Number of pages	7
Journal	Drug and Alcohol Dependence
Volume	159
DOIs	https://doi.org/10.1016/j.drugalcdep.2015.12.013
State	Published - Feb 1 2016

Funding

The authors wish to thank to the AIDS Clinical Trials Group (ACTG) and SDMC. We would like to acknowledge the following individual sites’ grant support, study team members, and site personnel: Les Centres GHESKIO CRS (Site 30022) ACTG CTU Grant; Joint Clinical Research Centre CRS (Site 12401) ACTG CTU Grant U01- A1069501; Parirenyatwa CRS (Site 30313) ACTG CTU Grant UM 1AI069436; Wits HIV CRS (Site 11101) ACTG CTU Grant AI069463; Barranco CRS (Site 11301) ACTG CTU Grant 2UM1AI069438-08; San Miguel CRS (Site 11302) ACTG CTU Grant AI069438; Kalingalinga Clinic CRS (Site 12801) ACTG CTU Grant 7UMIA1069455; Gaborone Prevention/Treatment Trials CRS (Site 12701) ACTG CTU Grant 2UMIAI069456-08; CFDA Grant 93.865; Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS (Site 12101) ACTG CTU Grant AI069476 and Northwestern ACTG Grant 1U01AI069471. We also would like to thank to AbbVie Inc. and Gilead Pharmaceuticals, which provided the medications for the trial. The authors wish to thank to the AIDS Clinical Trials Group (ACTG) and SDMC. We would like to acknowledge the follow- ing individual sites’ grant support, study team members, and site personnel: Les Centres GHESKIO CRS (Site 30022) ACTG CTU Grant; Joint Clinical Research Centre CRS (Site 12401) ACTG CTU Grant U01- A1069501; Parirenyatwa CRS (Site 30313) ACTG CTU Grant UM 1AI069436; Wits HIV CRS (Site 11101) ACTG CTU Grant AI069463; Barranco CRS (Site 11301) ACTG CTU Grant 2UM1AI069438-08; San Miguel CRS (Site 11302) ACTG CTU Grant AI069438; Kalingalinga Clinic CRS (Site 12801) ACTG CTU Grant 7UMIA1069455; Gaborone Prevention/Treatment Trials CRS (Site 12701) ACTG CTU Grant 2UMIAI069456-08; CFDA Grant 93. 865; Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS (Site 12101) ACTG CTU Grant AI069476 and Northwestern ACTG Grant 1U01AI069471. We also would like to thank to AbbVie Inc. and Gilead Pharmaceuticals, which provided the medications for the trial.

Keywords

Adherence
Alcohol
Binge drinking
HIV/AIDS
Low and middle income countries
Microelectronic monitors

ASJC Scopus subject areas

Psychiatry and Mental health
Pharmacology (medical)
Toxicology
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.drugalcdep.2015.12.013

Cite this

De Boni, R. B., Zheng, L., Rosenkranz, S. L., Sun, X., Lavenberg, J., Cardoso, S. W., Grinsztejn, B., La Rosa, A., Pierre, S., Severe, P., Cohn, S. E., Collier, A. C., & Gross, R. (2016). Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals. Drug and Alcohol Dependence, 159, 174-180. https://doi.org/10.1016/j.drugalcdep.2015.12.013

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abstract = "Background: Understanding patterns of antiretroviral adherence and its predictors is important for designing tailored interventions. Alcohol use is associated with non-adherence. This study aimed to evaluate: (1) if there was a difference in weekday compared with weekend adherence in HIV-infected individuals from low and middle income countries (LMIC), and (2) whether binge drinking was associated with this difference. Methods: Data from a randomized trial conducted at 9 sites in 8 LMIC were analyzed. Microelectronic monitors were used to measure adherence. Differences between weekday and weekend adherence in each quarter (successive 12-week periods) were compared using Wilcoxon signed rank tests and predictors of adherence, including baseline binge drinking, were evaluated using Generalized Estimating Equations. Results: Data from 255 participants were analyzed: 49.8% were male, median age was 37 years and 28.6% enrolled in Haiti. At study entry, only 2.7% reported illicit substance use, but 22.3% reported binge drinking at least once in the 30 days prior to enrollment. Adherence was higher on weekdays than weekends (median percent doses taken: 96.0% vs 94.4%; 93.7% vs 91.7%; 92.6% vs 89.7% and 93.7% vs 89.7% in quarters 1-4 respectively, all p<. 0.001). Binge drinking at baseline and time on study were both associated with greater differences between weekday and weekend adherence. Conclusions: Adherence was worse on weekends compared to weekdays: difference was small at treatment initiation, increased over time and was associated with binge drinking. Screening and new interventions to address binge drinking, a potentially modifiable behavior, may improve adherence in HIV-infected individuals in LMIC.",

keywords = "Adherence, Alcohol, Binge drinking, HIV/AIDS, Low and middle income countries, Microelectronic monitors",

author = "{De Boni}, {Raquel B.} and Lu Zheng and Rosenkranz, {Susan L.} and Xin Sun and Jeffrey Lavenberg and Cardoso, {Sandra W.} and Beatriz Grinsztejn and {La Rosa}, Alberto and Samuel Pierre and Patrice Severe and Cohn, {Susan E.} and Collier, {Ann C.} and Robert Gross",

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doi = "10.1016/j.drugalcdep.2015.12.013",

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De Boni, RB, Zheng, L, Rosenkranz, SL, Sun, X, Lavenberg, J, Cardoso, SW, Grinsztejn, B, La Rosa, A, Pierre, S, Severe, P, Cohn, SE, Collier, AC & Gross, R 2016, 'Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals', Drug and Alcohol Dependence, vol. 159, pp. 174-180. https://doi.org/10.1016/j.drugalcdep.2015.12.013

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T1 - Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals

AU - De Boni, Raquel B.

AU - Zheng, Lu

AU - Rosenkranz, Susan L.

AU - Sun, Xin

AU - Lavenberg, Jeffrey

AU - Cardoso, Sandra W.

AU - Grinsztejn, Beatriz

AU - La Rosa, Alberto

AU - Pierre, Samuel

AU - Severe, Patrice

AU - Cohn, Susan E.

AU - Collier, Ann C.

AU - Gross, Robert

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N2 - Background: Understanding patterns of antiretroviral adherence and its predictors is important for designing tailored interventions. Alcohol use is associated with non-adherence. This study aimed to evaluate: (1) if there was a difference in weekday compared with weekend adherence in HIV-infected individuals from low and middle income countries (LMIC), and (2) whether binge drinking was associated with this difference. Methods: Data from a randomized trial conducted at 9 sites in 8 LMIC were analyzed. Microelectronic monitors were used to measure adherence. Differences between weekday and weekend adherence in each quarter (successive 12-week periods) were compared using Wilcoxon signed rank tests and predictors of adherence, including baseline binge drinking, were evaluated using Generalized Estimating Equations. Results: Data from 255 participants were analyzed: 49.8% were male, median age was 37 years and 28.6% enrolled in Haiti. At study entry, only 2.7% reported illicit substance use, but 22.3% reported binge drinking at least once in the 30 days prior to enrollment. Adherence was higher on weekdays than weekends (median percent doses taken: 96.0% vs 94.4%; 93.7% vs 91.7%; 92.6% vs 89.7% and 93.7% vs 89.7% in quarters 1-4 respectively, all p<. 0.001). Binge drinking at baseline and time on study were both associated with greater differences between weekday and weekend adherence. Conclusions: Adherence was worse on weekends compared to weekdays: difference was small at treatment initiation, increased over time and was associated with binge drinking. Screening and new interventions to address binge drinking, a potentially modifiable behavior, may improve adherence in HIV-infected individuals in LMIC.

AB - Background: Understanding patterns of antiretroviral adherence and its predictors is important for designing tailored interventions. Alcohol use is associated with non-adherence. This study aimed to evaluate: (1) if there was a difference in weekday compared with weekend adherence in HIV-infected individuals from low and middle income countries (LMIC), and (2) whether binge drinking was associated with this difference. Methods: Data from a randomized trial conducted at 9 sites in 8 LMIC were analyzed. Microelectronic monitors were used to measure adherence. Differences between weekday and weekend adherence in each quarter (successive 12-week periods) were compared using Wilcoxon signed rank tests and predictors of adherence, including baseline binge drinking, were evaluated using Generalized Estimating Equations. Results: Data from 255 participants were analyzed: 49.8% were male, median age was 37 years and 28.6% enrolled in Haiti. At study entry, only 2.7% reported illicit substance use, but 22.3% reported binge drinking at least once in the 30 days prior to enrollment. Adherence was higher on weekdays than weekends (median percent doses taken: 96.0% vs 94.4%; 93.7% vs 91.7%; 92.6% vs 89.7% and 93.7% vs 89.7% in quarters 1-4 respectively, all p<. 0.001). Binge drinking at baseline and time on study were both associated with greater differences between weekday and weekend adherence. Conclusions: Adherence was worse on weekends compared to weekdays: difference was small at treatment initiation, increased over time and was associated with binge drinking. Screening and new interventions to address binge drinking, a potentially modifiable behavior, may improve adherence in HIV-infected individuals in LMIC.

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Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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