Bio-barcodes based on oligonucleotide-modified nanoparticles

Jwa Min Nam, So Jung Park, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

260 Scopus citations

Abstract

By utilizing oligonucleotide-modified Au nanoparticles encoded with sequences that act as biobarcodes, one can screen for multiple target polyvalent proteins simultaneously in one solution. This novel concept was demonstrated with two types of detection formats, a homogeneous assay and one based on oligonucleotide microarrays. With such an approach, one can prepare an extraordinarily large number of barcodes from synthetically accessible oligonucleotides (e.g., a 12-mer sequence offers 412 possible barcodes).

Original languageEnglish (US)
Pages (from-to)3820-3821
Number of pages2
JournalJournal of the American Chemical Society
Volume124
Issue number15
DOIs
StatePublished - Apr 17 2002

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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