Bio-barcodes based on oligonucleotide-modified nanoparticles

Jwa Min Nam; So Jung Park; Chad A. Mirkin

doi:10.1021/ja0178766

Bio-barcodes based on oligonucleotide-modified nanoparticles

Jwa Min Nam, So Jung Park, Chad A. Mirkin^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

271 Scopus citations

Abstract

By utilizing oligonucleotide-modified Au nanoparticles encoded with sequences that act as biobarcodes, one can screen for multiple target polyvalent proteins simultaneously in one solution. This novel concept was demonstrated with two types of detection formats, a homogeneous assay and one based on oligonucleotide microarrays. With such an approach, one can prepare an extraordinarily large number of barcodes from synthetically accessible oligonucleotides (e.g., a 12-mer sequence offers 4¹² possible barcodes).

Original language	English (US)
Pages (from-to)	3820-3821
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	124
Issue number	15
DOIs	https://doi.org/10.1021/ja0178766
State	Published - Apr 17 2002

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0178766

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abstract = "By utilizing oligonucleotide-modified Au nanoparticles encoded with sequences that act as biobarcodes, one can screen for multiple target polyvalent proteins simultaneously in one solution. This novel concept was demonstrated with two types of detection formats, a homogeneous assay and one based on oligonucleotide microarrays. With such an approach, one can prepare an extraordinarily large number of barcodes from synthetically accessible oligonucleotides (e.g., a 12-mer sequence offers 412 possible barcodes).",

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Bio-barcodes based on oligonucleotide-modified nanoparticles

Abstract

ASJC Scopus subject areas

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