Bioactive and therapeutic ROMP polymers

Deedee Smith, Emily B. Pentzer, Sonbinh T. Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

This review summarizes the developments in the area of ROMP-based polymer carriers as well as side-chain and main-chain polymer therapeutics during the period of 1993-2007. The promising emergence of ROMP-derived amphiphilic block copolymers containing therapeutic agents, their assembly into polymer nanoparticles, together with their modification for the targeting group attachment is outlined. Recent application of ROMP-based side-chain polymer therapeutics as multivalent scaffolds and the synthesis of DIVEMA-type main-chain polymers from ROMP-active monomers are also discussed. Finally, an outlook on the opportunities and the future directions in the use of ROMP towards the development of the next generation of polymer therapeutics is provided.

Original languageEnglish (US)
Pages (from-to)419-459
Number of pages41
JournalPolymer Reviews
Volume47
Issue number3
DOIs
StatePublished - Jul 2007

Keywords

  • Drug delivery
  • Plymer nanoparticles
  • Polymer micelles
  • Polymer therapeutics
  • ROMP
  • Targeting

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Chemistry(all)
  • Renewable Energy, Sustainability and the Environment
  • Biomedical Engineering
  • Polymers and Plastics
  • Materials Chemistry
  • Electrical and Electronic Engineering

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