Bioactive Peptide Brush Polymers via Photoinduced Reversible-Deactivation Radical Polymerization

Hao Sun, Wonmin Choi, Nanzhi Zang, Claudia Battistella, Matthew P. Thompson, Wei Cao, Xuhao Zhou, Christopher Forman, Nathan C. Gianneschi*

*Corresponding author for this work

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Harnessing metal-free photoinduced reversible-deactivation radical polymerization (photo-RDRP) in organic and aqueous phases, we report a synthetic approach to enzyme-responsive and pro-apoptotic peptide brush polymers. Thermolysin-responsive peptide-based polymeric amphiphiles assembled into spherical micellar nanoparticles that undergo a morphology transition to worm-like micelles upon enzyme-triggered cleavage of coronal peptide sidechains. Moreover, pro-apoptotic polypeptide brushes show enhanced cell uptake over individual peptide chains of the same sequence, resulting in a significant increase in cytotoxicity to cancer cells. Critically, increased grafting density of pro-apoptotic peptides on brush polymers correlates with increased uptake efficiency and concurrently, cytotoxicity. The mild synthetic conditions afforded by photo-RDRP, make it possible to access well-defined peptide-based polymer bioconjugate structures with tunable bioactivity.

Original languageEnglish (US)
Pages (from-to)17359-17364
Number of pages6
JournalAngewandte Chemie - International Edition
Volume58
Issue number48
DOIs
StatePublished - Nov 25 2019

Keywords

  • biomaterials
  • nanomaterials
  • peptide brush polymer
  • photochemistry
  • polymerization

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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