Bioactive protein nanoarrays on nickel oxide surfaces formed by dip-pen nanolithography

Jwa Min Nam, Sang Woo Han, Ki Bum Lee, Xiaogang Liu, Mark A. Ratner, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


Ink flowing from a pen: Direct-write dippen nanolithography of His-tagged proteins (ubiquitin and thioredoxin) has been used to generate biologically active protein nanoarrays with feature sizes as small as 80 nm on nickel oxide surfaces without the need for an applied electric field. The protein molecules in this system seem to diffuse from the Ni-coated atomic force microscopy (AFM) tips to the Ni-coated substrate (see diagram).

Original languageEnglish (US)
Pages (from-to)1246-1249
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number10
StatePublished - Feb 27 2004


  • Atomic force microscopy
  • Nanolithography
  • Nickel
  • Protein arrays
  • Proteins

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis


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