BioCARS: A synchrotron resource for time-resolved X-ray science

T. Graber*, S. Anderson, H. Brewer, Y. S. Chen, H. S. Cho, N. Dashdorj, R. W. Henning, I. Kosheleva, G. MacHa, M. Meron, R. Pahl, Z. Ren, S. Ruan, F. Schotte, V. Šrajer, P. J. Viccaro, F. Westferro, P. Anfinrud, K. Moffat

*Corresponding author for this work

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

BioCARS, a NIH-supported national user facility for macromolecular time-resolved X-ray crystallography at the Advanced Photon Source (APS), has recently completed commissioning of an upgraded undulator-based beamline optimized for single-shot laser-pump X-ray-probe measurements with time resolution as short as 100 ps. The source consists of two in-line undulators with periods of 23 and 27 mm that together provide high-flux pink-beam capability at 12 keV as well as first-harmonic coverage from 6.8 to 19 keV. A high-heat-load chopper reduces the average power load on downstream components, thereby preserving the surface figure of a Kirkpatrick-Baez mirror system capable of focusing the X-ray beam to a spot size of 90 m horizontal by 20 m vertical. A high-speed chopper isolates single X-ray pulses at 1 kHz in both hybrid and 24-bunch modes of the APS storage ring. In hybrid mode each isolated X-ray pulse delivers up to ∼4 × 1010 photons to the sample, thereby achieving a time-averaged flux approaching that of fourth-generation X-FEL sources. A new high-power picosecond laser system delivers pulses tunable over the wavelength range 450-2000 nm. These pulses are synchronized to the storage-ring RF clock with long-term stability better than 10 ps RMS. Monochromatic experimental capability with Biosafety Level 3 certification has been retained.

Original languageEnglish (US)
Pages (from-to)658-670
Number of pages13
JournalJournal of Synchrotron Radiation
Volume18
Issue number4
DOIs
StatePublished - Jul 2011

Keywords

  • Laue crystallography
  • X-ray optics
  • synchrotron beamline
  • time-resolved crystallography

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Instrumentation

Fingerprint Dive into the research topics of 'BioCARS: A synchrotron resource for time-resolved X-ray science'. Together they form a unique fingerprint.

  • Cite this

    Graber, T., Anderson, S., Brewer, H., Chen, Y. S., Cho, H. S., Dashdorj, N., Henning, R. W., Kosheleva, I., MacHa, G., Meron, M., Pahl, R., Ren, Z., Ruan, S., Schotte, F., Šrajer, V., Viccaro, P. J., Westferro, F., Anfinrud, P., & Moffat, K. (2011). BioCARS: A synchrotron resource for time-resolved X-ray science. Journal of Synchrotron Radiation, 18(4), 658-670. https://doi.org/10.1107/S0909049511009423